Fluctuations in serological hepatitis C virus levels in HIV patients
| Autor: | Adriana Parise Compri, Vanessa Cristina Martins Silva, Isabel Takano Oba, Regina Célia Moreira, Marcilio Figueiredo Lemos, Samira Julien Calux, Maria Cassia Mendes-Correa, Ana Paula de Torres Santos |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Microbiology (medical)
Male lcsh:Arctic medicine. Tropical medicine Genotype lcsh:RC955-962 Hepacivirus Hepatitis C virus 030231 tropical medicine HIV Infections medicine.disease_cause Real-Time Polymerase Chain Reaction Serology 03 medical and health sciences 0302 clinical medicine medicine Humans biology Transmission (medicine) business.industry Coinfection Human immunodeficiency virus virus diseases Hepatitis C Fluctuation Hepatitis C Antibodies Middle Aged Viral Load biology.organism_classification medicine.disease Virology digestive system diseases CD4 Lymphocyte Count Infectious Diseases Population study RNA Viral 030211 gastroenterology & hepatology Parasitology Female business Hepatitis C vírus Viral load |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical v.51 n.6 2018 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT Revista da Sociedade Brasileira de Medicina Tropical, Volume: 51, Issue: 6, Pages: 737-741, Published: DEC 2018 Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 6, Pp 737-741 |
| Popis: | INTRODUCTION: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) have identical transmission routes, explaining the high prevalence of coinfections. The main aim of this study was to detect fluctuations in serological HCV levels in HIV patients. METHODS: We analyzed samples of 147 patients who attended an outpatient service that supports HIV/AIDS patients in São Paulo city. We also recruited 22 HCV-monoinfected patients who attended the Instituto Adolfo Lutz Laboratory in São Paulo city, to compare the test results. Serological testing of the blood samples was performed for the detection of HCV antibodies. The samples were then analyzed using real-time PCR for RNA viral quantification and sequencing. RESULTS We found that 13.6% of the study population was coinfected with HIV and HCV. In 20% of coinfected patients, fluctuations in serology results were detected in samples collected during the follow-up. No changes in anti-HCV serological markers were observed in HCV-monoinfected patients. An HCV viral load was detected in 9,5% of the samples collected from HIV patients. CONCLUSIONS: Our findings provide important clinical data to public health professionals and highlight the importance of periodic monitoring of HCV/HIV coinfected patients. |
| Databáze: | OpenAIRE |
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