Diagnostic and prognostic impact of copeptin and high-sensitivity cardiac troponin T in patients with pre-existing coronary artery disease and suspected acute myocardial infarction
| Autor: | Philip Haaf, Katrin Winkler, Simone Thalmann, Miriam Reiter, Raphael Twerenbold, Beatrice Drexler, Stefano Bassetti, Christian Mueller, Christa Zellweger, Claudia Stelzig, Cathrin Balmelli, Michael Freese, Tobias Reichlin, Stephan Steuer, Stefan Osswald, Mihael Potocki, Willibald Hochholzer |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction Coronary Artery Disease 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences Electrocardiography 0302 clinical medicine Copeptin Troponin complex Troponin T Predictive Value of Tests Internal medicine Medicine Humans cardiovascular diseases 030212 general & internal medicine Myocardial infarction Prospective Studies Protein Precursors Prospective cohort study Aged medicine.diagnostic_test business.industry Glycopeptides Middle Aged medicine.disease Prognosis 3. Good health Survival Rate Early Diagnosis ROC Curve Predictive value of tests Cardiology Female Myocardial infarction diagnosis Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies |
| Zdroj: | Heart (British Cardiac Society) |
| DOI: | 10.1136/heartjnl-2011-301269 |
| Popis: | OBJECTIVE The early diagnosis of acute myocardial infarction (AMI) can be particularly challenging in patients with known coronary artery disease (CAD) due to pre existing ECG changes and chronic increases in cardiac troponin (cTn) levels. DESIGN Of 1170 consecutive patients presenting with symptoms suggestive of AMI 433 (37) with pre existing CAD were analysed in a prospective multicentre study and the diagnostic and prognostic impact of copeptin in combination with either fourth generation cardiac troponin T (cTnT) or high sensitivity cTnT (hs cTnT) was evaluated. RESULTS AMI was the final diagnosis in 78 patients with pre existing CAD (18). Copeptin was significantly higher in patients with AMI than in those without (26 pmol/l (IQR 9 71) vs 7 pmol/l (IQR 4 16) p |
| Databáze: | OpenAIRE |
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