Does progesterone administration in preterm labor influence Treg cells?
| Autor: | Paulo Rodrigues-Santos, Ana Vaz-Ambrósio, Vera Alves, Sofia Vale-Pereira, Ana Luísa Areia, Paulo Moura, Anabela Mota-Pinto, Manuel Santos Rosa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Tocolytic agent medicine.medical_specialty Preterm labor Tocolysis Pilot Projects Single Center T-Lymphocytes Regulatory Treg cell Flow cytometry Andrology 03 medical and health sciences Treggs Obstetric Labor Premature Vasotocin 0302 clinical medicine Pregnancy medicine Humans Progesterone 030219 obstetrics & reproductive medicine medicine.diagnostic_test Obstetrics business.industry Obstetrics and Gynecology Flow Cytometry medicine.disease Tocolytic Agents Treatment Outcome 030104 developmental biology Pediatrics Perinatology and Child Health Cohort Female Tocolytic treatment business Biomarkers |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | Objectives: The aim of this study was to determine if the actions of progesterone on preterm labor are accomplished through modulation of the percentage of regulatory T-cells (Treg). Methods: The study was a cohort pilot study made in a single center tertiary obstetrical unit with women in preterm labor arrested with tocolytic treatment. Variation of the number and percentage of Treg cells obtained from peripheral blood samples of women with preterm labor were calculated by flow cytometry, before and after progesterone administration. Results: In the paired samples for each patient, there was a significant difference in the Treg cell pool after progesterone treatment, with an increase in both their percentage (48.9 vs. 53; P = 0.07) and absolute number (14.8 vs. 56.5 cells/μL; P = 0.046). Conclusions: This research demonstrated a considerable increase in the Treg cell pool after progesterone treatment. This indicates a possible mechanism for progesterone treatment benefits in preterm labor, potentially increasing its more rational use. |
| Databáze: | OpenAIRE |
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