Free radical activity during development of insulin-dependent diabetes mellitus in the rat
| Autor: | Olli Pitkänen, Sture Andersson, Mikko Hallman, Hannu Sariola, Julio M Martin, Hans K. Åkerblom |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Lipid Peroxides Free Radicals 030209 endocrinology & metabolism Disease General Biochemistry Genetics and Molecular Biology Streptozocin Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fundamental difference Internal medicine Diabetes mellitus Pentanes medicine Animals Rats Inbred BB General Pharmacology Toxicology and Pharmaceutics 030304 developmental biology 0303 health sciences Chemistry Rats Inbred Strains General Medicine medicine.disease Rats Endocrinology Diabetes Mellitus Type 1 Insulin dependent diabetes |
| Zdroj: | Life sciences. 50(5) |
| ISSN: | 0024-3205 |
| Popis: | Free radical-induced lipid peroxidation was quantified by measuring expired pentane from diabetic prone BB Wistar rats of 45-90 d of age. Insulin-dependent diabetes mellitus was manifest at the age of 71 +/- 8 d. Expired pentane increased from 2.1 +/- 0.7 to 5.0 +/- 3.0 pmol/100g/min (p less than 0.01) at manifestation of the disease and remained high throughout the test period. In healthy age-matched control rats it persisted low. In rats made diabetic with streptozotocin, expired pentane remained low. The changes in expired pentane suggest that the development of endogenous insulin-dependent diabetes mellitus in BB rats is associated with increased free radical activity. This is not due to hyperglycemia or ketosis per se, and reflects a fundamental difference in the free radical activity between the spontaneously diabetic BB rats and the disease produced by streptozotocin. Development of spontaneous insulin-dependent diabetes in BB rats is associated with increased free radical activity that persists after the manifestation of the disease. |
| Databáze: | OpenAIRE |
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