Metabolic syndrome and Cancer: Do they share common molecular pathways?
| Autor: | N. Ziras, I. Sofatzis, E. Veniou, I. Kalantzis, M. Karakosta, M. Logothetis, E. Lianos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
obesity
cancer prevention business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer 030204 cardiovascular system & hematology Bioinformatics medicine.disease metabolic syndrome 03 medical and health sciences 0302 clinical medicine Oncology insulin resistance 030220 oncology & carcinogenesis Medicine Metabolic syndrome business RC254-282 lipokines |
| Zdroj: | Forum of Clinical Oncology, Vol 7, Iss 2, Pp 7-15 (2016) |
| ISSN: | 1792-362X |
| DOI: | 10.1515/fco-2016-0006 |
| Popis: | Metabolic syndrome, a clustering of risk factors including obesity, has emerged as a global health plague. A lot of epidemiological and clinical evidence suggests that the metabolic syndrome is linked not only to cardiovascular diseases and diabetes mellitus type 2 but also to cancer development and progression. In this review the potential mechanisms tying the metabolic syndrome with cancer are presented. The role of insulin resistance and hyperinsulinemia, the activation of insulin-like growth factor-1 (IGF-1) pathway, and the induction of cytotoxic products are highlighted. Subsequent effects leading to oxidative stress, release of lipokines with signaling properties by adipocytes, development of a sustained systemic inflammation, production of inflammatory cytokines, and establishment of a tumorigenic environment are also discussed. The importance of the metabolic syndrome and obesity coupled with the deeper understanding of the underlying molecular mechanisms has trigger intensive clinical research with an aim to prevent the risk of cancer and improve outcomes. Moreover, the need for lifestyle changes with increased physical activity and improved dietary quality has been emerged as urgent health priority. |
| Databáze: | OpenAIRE |
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