Toll-like receptors in rheumatic diseases: Are we paying a high price for our defense against bugs?
| Autor: | Kim C. M. Santegoets, W.B. van den Berg, Timothy R D J Radstake, L. van Bon, Mark H. Wenink |
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| Rok vydání: | 2011 |
| Předmět: |
Biophysics
Autoimmunity Inflammation medicine.disease_cause Biochemistry Psoriatic arthritis Immune system Toll-like receptor Structural Biology Rheumatic Diseases Genetics medicine Animals Humans Receptor Molecular Biology Innate immunity Innate immune system business.industry Toll-Like Receptors Models Immunological Cell Biology medicine.disease Infection and autoimmunity Auto-immunity transplantation and immunotherapy [NCMLS 1] Rheumatoid arthritis Immunology Rheumatologic disease medicine.symptom business |
| Zdroj: | FEBS Letters, 585, 3660-6 FEBS Letters, 585, 23, pp. 3660-6 |
| ISSN: | 0014-5793 |
| Popis: | Item does not contain fulltext In the last decade Toll-like receptor (TLR) research has led to new insights in the pathogenesis of many rheumatic diseases. In autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis TLR signaling is likely to be involved in tolerance breakthrough and chronic inflammation via combined Fc gamma receptors and TLR recognition of immune complexes. Furthermore, inflammatory diseases like psoriatic arthritis and gout also show more and more evidence for TLR involvement. In this review we will discuss the involvement of TLR signaling in several rheumatic diseases and stress their similarities and differences based on recent findings. |
| Databáze: | OpenAIRE |
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