Chromosomal Instability in Tumor Initiation and Development
| Autor: | Wei Zhang, Anil K. Sood, Duc-Hiep Bach |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Genome instability Cancer Research Tumor initiation urologic and male genital diseases medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Chromosomal Instability Chromosome Segregation Neoplasms Chromosome instability Humans Medicine neoplasms Chromothripsis business.industry virus diseases Cancer Aneuploidy medicine.disease Primary tumor female genital diseases and pregnancy complications surgical procedures operative 030104 developmental biology Oncology Drug Resistance Neoplasm Tumor progression 030220 oncology & carcinogenesis Cancer research Female business Carcinogenesis Precancerous Conditions |
| Zdroj: | Cancer Res |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-18-3235 |
| Popis: | Chromosomal instability (CIN) is one of the major forms of genomic instability in various human cancers and is recognized as a common hallmark of tumorigenesis and heterogeneity. However, some malignant tumors show a paucity of chromosomal alterations, suggesting that tumor progression and evolution can occur in the absence of CIN. It is unclear whether CIN is stable between precursor lesions, primary tumor, and metastases or if it evolves during these steps. In this review, we describe the influence of CIN on the various steps in tumor initiation and development. Given the recognized significant effects of CIN in cancer, CIN-targeted therapeutics could have a major impact on improving clinical outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|