Molecules produced by probiotics prevent enteric colibacillosis in pigs
| Autor: | Sapana Sharma, Chuan Wang, Zlatko Kovač, Rocio Morales, Mansel W. Griffiths, Akalate Tessema, Ricardo Nordeste |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Colon Swine Bioactive molecules 030106 microbiology Enteric colibacillosis Virulence Ileum Biology Weight Gain Microbiology 03 medical and health sciences Feces Lactobacillus acidophilus Antibiotic resistance medicine Animals Enterotoxigenic Escherichia coli Escherichia coli Infections 2. Zero hunger Swine Diseases lcsh:Veterinary medicine General Veterinary Probiotics Anti-virulence E. coli General Medicine 3. Good health Gastrointestinal Microbiome 030104 developmental biology medicine.anatomical_structure Proteobiotics Immunology lcsh:SF600-1100 Pigs Female medicine.symptom Weight gain Research Article |
| Zdroj: | BMC Veterinary Research BMC Veterinary Research, Vol 13, Iss 1, Pp 1-12 (2017) |
| ISSN: | 1746-6148 |
| Popis: | Background With the advent of antimicrobial resistance in animal pathogens, novel methods to combat infectious diseases are being sought. Among these, probiotics have been proposed as a means of promoting animal health but problems with their use has been reported. Research has demonstrated that bioactive molecules produced during the growth of certain probiotics interfere with bacterial cell-to-cell communication, which consequently results in an attenuation of virulence in a number of pathogens, including E. coli. The objective of this study was to determine the efficacy of the bioactive molecules, termed proteobiotics, produced by Lactobacillus acidophilus in preventing enterotoxigenic E, coli (ETEC) infection in pigs, which is the etiological agent for enteric colibacillosis, a common disease of nursing and young pigs. Results To achieve this, piglets were fed a preparation of the bioactive at four levels: 0, 0.5×, 1.0× and 2.0× for 7 days prior to challenge with E. coli K88. There were 36 pigs (18 gilts and 18 barrows) per treatment, resulting in 144 piglets in total for the study. Each pen had 6 piglets (3 gilts and 3 barrows). Only piglets with no physical abnormality or conditions were used in the trial and intact male piglets and ridglings were excluded. The bioactive continued to be fed to the pigs post-challenge. Based of fecal and demeanour scores, pigs fed the low and high dose of the proteobiotic were significanlty less likely to show symptoms of illness than pigs fed no bioactive. While not being significant, the weight gain of pigs given the proteobiotics was improved. At day 4 following challenge, almost 50% of piglets that did not receive the proteobiotic were shedding ETEC in their feces, compared with about 15% of animals receiving the supplement. There was also an indication that the proteobiotics reduced colonization of the ileum by E. coli K88 and improved gut health. Conclusion This study indicates that the bioactive molecules produced by L. acidophilus reduces incidence of enteric colibacillosis in pigs and their use on farms would help to reduce antibiotic use. |
| Databáze: | OpenAIRE |
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