Lidocaine treatment in pediatric convulsive status epilepticus
| Autor: | Metin Karaböcüoğlu, Nur Aydınlı, Agop Çıtak, Nedret Uzel, Raif Üçsel, Bilal Yildiz |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Phenytoin Lidocaine Convulsive status epilepticus business.industry medicine.medical_treatment medicine.disease Epilepsy Status Epilepticus Anticonvulsant Bolus (medicine) Child Preschool Anesthesia parasitic diseases Pediatrics Perinatology and Child Health medicine Humans Anticonvulsants Female Phenobarbital business Diazepam medicine.drug |
| Zdroj: | Pediatrics International. 50:35-39 |
| ISSN: | 1442-200X 1328-8067 |
| DOI: | 10.1111/j.1442-200x.2007.02510.x |
| Popis: | Background: Convulsive status epilepticus (CSE) may end fatally or leave serious sequelae. CSE treatment, invariably an emergency case, is based upon i.v. benzodiazepines as well as phenytoin, barbiturates or both. The present paper reports efficiency of lidocaine in CSE. Methods: The effects of lidocaine on patients with CSE due to infectious and non-infectious reasons were compared. Lidocaine was given in 29 episodes of CSE to 49 patients having failed to respond to first-line anticonvulsive drugs, such as diazepam, phenobarbital and phenytoin therapy. Lidocaine was given in doses of 2 mg/kg bolus i.v., and then in 4 mg/kg per h infusion. Results: Mean duration of lidocaine infusion was 14.6 ± 7.8 h. Effectiveness of lidocaine in patients with CSE was found to be 44.4%. Also, 11 patients responded to a single dose of lidocaine (37.9%), while another two (6.9%) required another dose to suppress their seizures. Patients with seizures attributable to infections were observed to have responded favorably to lidocaine when compared to those with seizures due to epilepsy (37.9% vs 6.8%; P |
| Databáze: | OpenAIRE |
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