Contribution of Co-detected Respiratory Viruses and Patient Age to the Clinical Manifestations of Mycoplasma Pneumoniae Pneumonia in Children
| Autor: | Do Kyun Kim, Ki Wook Yun, Mi Seon Han, Dong In Suh, Eun Hwa Choi, Kyuyol Rhie, Hoan Jong Lee, Ji Young Park, Joon Kee Lee, Hyunju Lee, Young Ho Kwak |
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| Rok vydání: | 2017 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Fever Virus 03 medical and health sciences 0302 clinical medicine Patient age Nasopharyngeal aspirate 030225 pediatrics Internal medicine Nasopharynx Pneumonia Mycoplasma Republic of Korea medicine Prevalence Humans 030212 general & internal medicine Respiratory system Child Mycoplasma pneumoniae pneumonia business.industry Coinfection Medical record medicine.disease respiratory tract diseases Anti-Bacterial Agents Mycoplasma pneumoniae Community-Acquired Infections Hospitalization Pneumonia Infectious Diseases Virus Diseases Child Preschool Pediatrics Perinatology and Child Health Immunology Viruses Respiratory virus Female business |
| Zdroj: | The Pediatric infectious disease journal. 37(6) |
| ISSN: | 1532-0987 |
| Popis: | The clinical spectrum of Mycoplasma pneumoniae pneumonia is widely variable. This study evaluated the clinical manifestations of M. pneumoniae pneumonia in children of different age groups and by the presence of co-detected respiratory virus.This study included children hospitalized with M. pneumoniae pneumonia between 2010 and 2015. At the time of pneumonia diagnosis, a nasopharyngeal aspirate was analyzed for respiratory viruses by reverse transcription-polymerase chain reaction (RT-PCR). The clinical manifestations and laboratory findings were reviewed from medical records.Of the 286 children with M. pneumoniae pneumonia, 84 (29.4%) had a co-detected respiratory virus, with the highest co-detection rate in young children (51.9% of children2 years; P = 0.002). In children2 years, with and without co-detected virus, wheezing occurred in 35.7% and 15.4%, respectively. Among the 202 children without any virus detected, only 6.4% were2 years. These young children showed fewer median days of fever than the children ≥2 years (8 vs. 11 days; P = 0.022). Children ≥2 years tended to have accompanying skin rashes (21.7% vs.7.7%; P = 0.310) and elevated liver enzymes (21.7% vs. 0%; P = 0.075) more frequently than children2 years. Only 53.8% of the patients2 years were treated with macrolide compared with 94.1% of the patients ≥2 years (P0.001).The clinical manifestations of M. pneumoniae pneumonia in young children are milder than those in older children. A high prevalence of co-detected respiratory virus in young children suggests that virus might play a role in making pneumonia clinically apparent in this age group. |
| Databáze: | OpenAIRE |
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