The Level of D-Dimer Is Positively Correlated With the Severity of Mycoplasma pneumoniae Pneumonia in Children
| Autor: | Zhimin Chen, Mengyao Li, Yan Zheng, Yuanyuan Zhang, Qiannan Zhao, Yingshuo Wang, Yunlian Zhou, Meixia Huang, Lingling Hua |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Mycoplasma pneumoniae medicine.medical_treatment Lymphocyte Immunology severity Thoracentesis 030204 cardiovascular system & hematology medicine.disease_cause Gastroenterology Microbiology Fibrin Fibrinogen Degradation Products 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cellular and Infection Microbiology children Internal medicine Oxygen therapy Lactate dehydrogenase D-dimer Pneumonia Mycoplasma medicine Humans pneumonia 030212 general & internal medicine Child Original Research Retrospective Studies Lung business.industry medicine.disease QR1-502 Pneumonia Infectious Diseases medicine.anatomical_structure chemistry business |
| Zdroj: | Frontiers in Cellular and Infection Microbiology, Vol 11 (2021) Frontiers in Cellular and Infection Microbiology |
| ISSN: | 2235-2988 |
| Popis: | ObjectiveMycoplasma pneumoniae pneumonia (MPP) is an important disease in children. Studies have demonstrated that the levels of D-dimer are elevated in some children with MPP, especially those with thrombotic complications. However, the potential association between MPP and D-dimer remains unclear. In our study, we sought to explore the relationship between the levels of plasma D-dimer and clinical characteristics of MPP patients.MethodsRetrospective analysis was conducted on 356 patients who were hospitalized in our hospital for MPP between January 1, 2017, and December 31, 2019. According to the peak value of D-dimer, patients were divided into three groups: the normal group (D-dimer5.5 mg/L). The demographic and clinical information, radiological findings, laboratory data, and treatments of patients were compared among different groups.Results106 patients were in the normal group, 204 patients were in the mild-moderately elevated group, and 46 patients were in the severely elevated group. More severe clinical and radiographic manifestations, longer length of fever, hospital stay and antibiotic therapy duration, higher incidences of extra-pulmonary complications, refractory MPP (RMPP), severe MPP (SMPP) were found in the elevated group, when compared with the normal group (P8+ lymphocyte (CD8+%), C-reactive protein (CRP), lactate dehydrogenase (LDH), interleukin (IL)-6, IL-10, and interferon-gamma (IFN-γ) trended higher with increasing D-dimer, whereas the percentage of lymphocyte (L%) and prealbumin (PAB) trended lower (PPConclusionsMPP patients with higher levels of D-dimer had more severe clinical manifestations and needed longer duration of treatment, which might be closely related to the severity of lung inflammation after MP infection. |
| Databáze: | OpenAIRE |
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