PLASMA CHOLECYSTOKININ AND HEPATIC ENZYMES, CHOLESTEROL AND LIPOPROTEINS IN AMMONIUM PERFLUOROOCTANOATE PRODUCTION WORKERS

Autor:	Michele M. Burlew, Geary W. Olsen, Jeffrey H. Mandel, Jean M. Burris
Rok vydání:	2000
Předmět:	Male medicine.medical_specialty Alcohol Drinking Lipoproteins Health Toxicology and Mutagenesis Radioimmunoassay Toxicology Gas Chromatography-Mass Spectrometry Body Mass Index chemistry.chemical_compound Cholestasis Occupational Exposure Internal medicine medicine Acinar cell Humans Carcinogen Cholecystokinin Pharmacology Analysis of Variance Fluorocarbons Chemical Health and Safety Chemistry Cholesterol Public Health Environmental and Occupational Health Alanine Transaminase General Medicine medicine.disease Endocrinology Liver Population Surveillance Toxicity Regression Analysis Perfluorooctanoic acid Peroxisome Proliferators Caprylates Lipoprotein
Zdroj:	Drug and Chemical Toxicology. 23:603-620
ISSN:	1525-6014 0148-0545
DOI:	10.1081/dct-100101973
Popis:	Ammonium perfluorooctanoate is a potent synthetic surfactant used in industrial applications. It rapidly dissociates in biologic media to perfluorooctanoate [CF3(CF2)6CO2-], which is the anion of perfluorooctanoic acid [PFOA, CF3(CF2)6COOH]. PFOA is a peroxisome proliferator known to increase the incidence of hepatic, pancreas and Leydig cell adenomas in rats. The pancreas acinar cell adenomas may be the consequence of a mild but sustained increase of cholecystokinin as a result of hepatic cholestasis. Although no significant clinical hepatic toxicity was observed, PFOA was reported to have modulated hepatic responses to obesity and alcohol consumption among production workers. To further assess these hypotheses, we examined medical surveillance data of male workers involved in ammonium perfluorooctanoate production in 1993 (n=111), 1995 (n=80) and 1997 (n=74). Serum PFOA was measured by high-performance liquid chromatography mass spectrometry methods. Plasma cholecystokinin was measured (only in 1997) by the use of direct radioimmunoassay. Serum biochemical tests included hepatic enzymes, cholesterol and lipoproteins. Serum PFOA levels, by year, were: 1993 (mean 5.0 ppm, SD 12.2, median 1.1 ppm, range 0.0-80.0 ppm); 1995 (mean 6.8 ppm, SD 16.0, median 1.2 ppm, range 0.0-114.1 ppm); and 1997 (mean 6.4 ppm, SD 14.3, median 1.3 ppm, range 0.1-81.3 ppm). Cholecystokinin values (mean 28.5 pg/ml, SD 17.1, median 22.7 pg/ml, range 8.8-86.7 pg/ml) approximated the assay's reference range (up to 80 pg/ml) for a 12 hour fast and were negatively, not positively, associated with employees' serum PFOA levels. Our findings continue to suggest there is no significant clinical hepatic toxicity associated with PFOA levels as measured in this workforce. Unlike a previously reported observation, PFOA did not appear to modulate hepatic responses to either obesity or alcohol consumption. Limitations of these findings include: 1) the cross-sectional design as only 17 subjects were common for the three surveillance years; 2) the voluntary participation that ranged between 50 and 70 percent; and 3) the few subjects with serum levelsor = 10 ppm.
Databáze:	OpenAIRE
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