Gallbladder filling and post-ceruletide emptying in prairie dogs and rabbits
| Autor: | G. T. Krishnamurthy, Fredrick E. Turner |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Prairie dog Gastroenterology Xylazine Cholelithiasis biology.animal Internal medicine Intestine Small medicine Animals Bile Humans Radiology Nuclear Medicine and imaging Ketamine Ceruletide Ejection fraction biology business.industry Gallbladder Sciuridae General Medicine Gallstones medicine.disease Hepatic bile medicine.anatomical_structure Rabbits business medicine.drug |
| Zdroj: | Nuclear Medicine Communications. 9:382-388 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-198805000-00011 |
| Popis: | The filling and emptying characteristics of the gallbladder in prairie dogs and rabbits were studied to assess the importance of the residual bile in the pathogenesis of gallstones. In prairie dogs under ketamine/xylazine anesthesia, a significantly larger fraction (p = 0.001) of hepatic bile entered the gallbladder (87 +/- 8%) than the intestine during fasting and very little bile emptied (0-3% ejection fraction) following ceruletide infusion. In rabbits under similar anesthesia, only a small fraction of hepatic bile entered the gallbladder (4 +/- 2%) during fasting, and the gallbladder emptied almost completely (85% ejection fraction) following ceruletide infusion. The resultant higher residual bile in the prairie dog gallbladder and lower residual bile in the rabbit gallbladder may explain why gallstones form so readily in prairie dogs but not in rabbits when fed a lithogenic diet. These similarities and differences in gallbladder function must be taken into account when considering any animal as a model for gallstone formation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|