A review on Coronavirus Disease and potentially active drugs targeting Coronavirus
| Autor: | Kamal Shah, Manish Sinha, Bansal Nitin, Nagendra Singh Chauhan, Tarawanti Verma, Shyam Raj Yadav |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
viruses
Population coronavirus remdesivir Disease medicine.disease_cause Virus Coronavirinae antivirals Medicine education Nose Coronavirus education.field_of_study biology business.industry Mortality rate ace2 receptors virus diseases biology.organism_classification medicine.disease Virology medicine.anatomical_structure coronavirus disease cytokine storm business Cytokine storm TP248.13-248.65 severe acute respiratory syndrome coronavirus 2 Biotechnology |
| Zdroj: | Biomedical and Biotechnology Research Journal, Vol 5, Iss 2, Pp 110-120 (2021) |
| ISSN: | 2588-9834 |
| DOI: | 10.4103/bbrj.bbrj_14_21 |
| Popis: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus with single positive-strand RNA, having glycoproteins projection on envelopes so reveals a halo-like appearance or corona. Coronavirus is of four types: (1) α-coronavirus (α-COV); (2) β-coronavirus (β-COV); (3) δ-coronavirus (δ-COV); and (4) γ-coronavirus (γ-COV) and belongs to family Coronaviridae and subfamily Coronavirinae. Coronaviruses are the normal pathogens that cause broad band of gastrointestinal and respiratory diseases in domestic as well as wild animals such as pigs, birds, and rodents. Coronavirus is highly infectious in case of elders for mortality rate. The elder peoples are at 2-fold higher risk as compared to the younger population and the greater part of the population dying from coronavirus disease (COVID-19) is male. The virus enters into the body by the mouth, eyes, or nose, then particles march inside of the body by different pathways and affect vital organs in severe ways such as liver, heart muscle, blood vessels, kidneys, central nervous system, etc. Right now, the only solution to avoid COVID-19 infection is “precautions.” Different companies of different countries at different steps are in race to develop effective medicines for treatment and management of the same. Here, in this review, we tried to give an overview of all about SARS-CoV-2, COVID-19 infection, pathophysiology, mechanisms, and various treatment trials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|