ANALYSIS OF THE COMPONENTS OF THE HYPERCALCAEMIA IN A 14-YEAR-OLD BOY FOLLOWING PROLONGED IMMOBILISATION
| Autor: | M. D. Penney, J. B. Dibble |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Hypercalcaemia Adolescent Urinary system medicine.medical_treatment chemistry.chemical_element Calcium Bed rest Phosphates Immobilization chemistry.chemical_compound Internal medicine Cyclic AMP medicine Humans Saline Serum Albumin Calcium metabolism business.industry General Medicine Phosphate medicine.disease Endocrinology chemistry Parathyroid Hormone Renal physiology Pediatrics Perinatology and Child Health Hypercalcemia business Glomerular Filtration Rate |
| Zdroj: | Acta Paediatrica. 72:207-210 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1983.tb09698.x |
| Popis: | A fourteen-year-old boy developed severe symptomatic hypercalcaemia following prolonged supine bed rest for major trauma. Treatment consisted initially of intravenous saline and frusemide together with oral phosphate, followed by intramuscular salmon calcitonin. Only after mobilisation and weight bearing was a sustained fall of plasma calcium to normal achieved. Plasma immunoreactive parathormone levels using both N-terminal and mixed terminal specific antisera were always undetectable and urinary cyclic AMP levels were within the normal range throughout. However, before mobilisation, the tubular reabsorption of phosphate was reduced and that of calcium was increased thus indirectly suggesting increased parathormone activity. The hypercalcaemia was due to a combination of increased calcium release from bone and increased tubular reabsorption. We suggest that a factor other than parathormone is responsible for altered tubular handling of calcium and phosphate which develop following prolonged immobilisation in these patients. |
| Databáze: | OpenAIRE |
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