Cerebellar involvement in essential tremor with and without resting tremor: A Diffusion Tensor Imaging study
| Autor: | Maria Eugenia Caligiuri, Aldo Quattrone, Maria Grazia Vaccaro, Salvatore M Cavalli, Fabiana Novellino, Maurizio Morelli, Gennarina Arabia, Rita Nisticò, Carmelina Chiriaco, Maria Salsone, Andrea Cherubini, Giuseppe Nicoletti |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Cerebellum Pathology medicine.medical_specialty Grey matter 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Tremor Fractional anisotropy medicine Humans Resting tremor Aged Aged 80 and over Essential tremor Neurodegeneration Middle Aged medicine.disease Pathophysiology Structural MRI Diffusion Tensor Imaging medicine.anatomical_structure nervous system Neurology DTI Female Neurology (clinical) Geriatrics and Gerontology Psychology 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Parkinsonism & related disorders 27 (2016): 60–66. doi:10.1016/j.parkreldis.2016.03.022 info:cnr-pdr/source/autori:Novellino F.; Nicoletti G.; Cherubini A.; Caligiuri M.E.; Nistico R.; Salsone M.; Morelli M.; Arabia G.; Cavalli S.M.; Vaccaro M.G.; Chiriaco C.; Quattrone A./titolo:Cerebellar involvement in essential tremor with and without resting tremor: A Diffusion Tensor Imaging study/doi:10.1016%2Fj.parkreldis.2016.03.022/rivista:Parkinsonism & related disorders/anno:2016/pagina_da:60/pagina_a:66/intervallo_pagine:60–66/volume:27 |
| ISSN: | 1353-8020 |
| Popis: | Objective Essential Tremor with resting tremor (rET) is a debated and poorly understood clinical phenotype. Converging evidences show that neurodegeneration of the cerebellum underlies the pathophysiology of ET, but it is not known if cerebellar changes also occurs in patients with rET. The aim of our study was to evaluate cerebellar microstructure in patients with ET with- (rET) and without resting tremor (ETwr) in comparison to healthy controls by MR Diffusion Tensor Imaging (DTI). Methods We studied 67 patients with ET (rET: 29 and ETwr: 38) and 39 age-matched healthy controls (HC). DTI was performed to measure fractional anisotropy (FA) and mean diffusivity (MD) of white and grey matter (WM, GM) in the entire cerebellum and in right and left cerebellar hemispheres. Results MD was significantly higher in the cerebellar GM of ET total group (10.39 ± 0.87) in comparison with HC (9.90 ± 0.71) (p = 0.0027). Interestingly, MD was significantly different when ETwr (10.48 ± 0.77) were compared with HC (p = 0.0017), whereas a trend toward significance were found between rET (10.29 ± 0.99) and HC (p = 0.067). No differences among groups were found in MD of cerebellar WM and in FA values neither in the WM nor in the GM. Conclusion Our results demonstrate the presence of microstructural changes in the cerebellum of patients with ET. It is noteworthy that rET showed intermediate values compared to HC and ETwr, suggesting that rET shares part of the pathophysiological mechanisms of ETwr, but cerebellar involvement seems do not fully account for rET. In addition to the cerebellar loops, other networks may play a role in rET pathophysiology. |
| Databáze: | OpenAIRE |
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