Corrosion protection of AZ31 alloy and constrained bacterial adhesion mediated by a polymeric coating obtained from a phytocompound

Autor: Claudia A. Grillo, M. Fernández Lorenzo de Mele, Marcos Bertuola, María Cecilia Cortizo, Alejandro Miñán
Rok vydání: 2018
Předmět:
Staphylococcus aureus
CIENCIAS MÉDICAS Y DE LA SALUD
Polymers
Surface Properties
Phytochemicals
Alloy
BIODEGRADABLE
CORROSION PRODUCTS
chemistry.chemical_element
02 engineering and technology
engineering.material
010402 general chemistry
01 natural sciences
Bacterial Adhesion
Polymerization
Biomateriales
Biotecnología de la Salud
Corrosion
Colloid and Surface Chemistry
Coated Materials
Biocompatible
Coating
Spectroscopy
Fourier Transform Infrared
Alloys
Electrochemistry
Magnesium
Physical and Theoretical Chemistry
STAPHYLOCOCCUS AUREUS
Ions
Microbial Viability
Biofilm
Spectrometry
X-Ray Emission
Biomaterial
Surfaces and Interfaces
General Medicine
Adhesion
THYMOL ELECTROPOLYMERIZATION
021001 nanoscience & nanotechnology
Thymol
Anti-Bacterial Agents
0104 chemical sciences
chemistry
Chemical engineering
MG ALLOY
engineering
0210 nano-technology
Layer (electronics)
Biotechnology
Titanium
Zdroj: Colloids and Surfaces B: Biointerfaces. 172:187-196
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2018.08.025
Popis: The prevention of microbial biofilm formation on a biomaterial surface is crucial in avoiding implants failures and the development of antibiotic resistant bacteria. It was reported that biodegradable Mg alloys may show antimicrobial effects due to the alkalinization of the corroding area. However, this issue is controversial and deserves a detailed study, since the processes occurring at the [biodegradable metal/biological medium] interface are complex and varied. Results showed that bacterial adhesion on AZ31 was lower than that of the titanium control and revealed that was dependent on surface composition, depicting some preferential sites for bacterial attachment (C-, P-, O-containing corrosion products) and others that are particularly avoided (active corrosion sites). As a key challenge, a strategy able to improve the performance of Mg alloys by both, reducing the formation of corrosion products and inhibiting bacterial adhesion was subsequently developed. A polymeric layer (polyTOH) was obtained by electropolymerization of thymol (TOH), a phytophenolic compound. The polyTOH can operate as a multifunctional film that improves the surface characteristics of the AZ31 Mg alloy by enhancing corrosion resistance (ions release was reduced to almost the half during the first days) and create an anti-adherent surface (bacterial attachment was 30-fold lower on polyTOH-AZ31 than on non-coated Mg alloy and 200-fold lower than Ti control and was constrained to specific regions). This anti-adherent property implies an additional advantage: enhancement of the efficacy of antibiotic treatments. Fil: Bertuola, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina Fil: Miñan, Alejandro Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina Fil: Grillo, Claudia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina Fil: Salsa Cortizo, Maria Victoria. Universidad Nacional de La Plata. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina Fil: Fernandez Lorenzo, Monica Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; Argentina
Databáze: OpenAIRE
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