Association of IL‐17A‐197G/A and IL‐17F‐7488T/C polymorphisms and osteoarthritis susceptibility: A meta‐analysis
| Autor: | Shu-Tao Gao, Weibin Sheng, Qiang Deng, Chao Mao, Jie Cheng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Population Osteoarthritis Cochrane Library Polymorphism Single Nucleotide Gastroenterology 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine Genetic model medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine education 030203 arthritis & rheumatology education.field_of_study business.industry Interleukin-17 DNA Odds ratio medicine.disease Confidence interval Meta-analysis Dominant model business |
| Zdroj: | International Journal of Rheumatic Diseases. 23:37-46 |
| ISSN: | 1756-185X 1756-1841 |
| DOI: | 10.1111/1756-185x.13737 |
| Popis: | AIM This meta-analysis was conducted with the aim of collecting and synthesizing the existing evidence on the association of interleukin-17A (IL-17A)-197G/A and IL-17F-7488T/C gene polymorphisms and osteoarthritis (OA) susceptibility. METHODS Six electronic databases including PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, and Wanfang were systematically searched for potentially relevant studies previous to June 2019. The strengths of association were estimated by summary odds ratios (ORs) and 95% confidence intervals (95%CIs) in a model-free approach. Heterogeneity test and sensitivity analysis were also conducted to guarantee the reliability of this study. RESULTS Six eligible case-control studies comprising 1989 OA patients and 2116 healthy controls were obtained for the meta-analysis. Dominant model was confirmed to be the optimal genetic model (MM + Mm vs mm). The pooled estimate supported that IL-17A-197G/A and IL-17F-7488T/C polymorphisms were significantly associated with OA susceptibility in the overall population (IL-17A-197G/A: GG + GA vs AA, OR = 0.69, 95%CI 0.57-0.80; P |
| Databáze: | OpenAIRE |
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