Prenatal and Postnatal Medical Conditions and the Risk of Brain Tumors in Children and Adolescents: An International Multicenter Case-Control Study
| Autor: | Martin Röösli, Maral Adel Fahmideh, Claudia E. Kuehni, Tore Tynes, Lisbeth Samsø Schmidt, Giorgio Tettamanti, Birgitta Lannering, Maria Feychting, Xiaochen Shu, Michael A. Grotzer, Joachim Schüz, Danielle Vienneau, Christoffer Johansen, Lars Klaeboe |
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| Přispěvatelé: | University of Zurich, Tettamanti, Giorgio |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatrics Internationality Epidemiology Denmark 0302 clinical medicine Pregnancy Odds Ratio 030212 general & internal medicine Child education.field_of_study Brain Neoplasms Norway Head injury Prenatal Care Radiation Exposure Magnetic Resonance Imaging 3. Good health Oncology 030220 oncology & carcinogenesis Prenatal Exposure Delayed Effects 2730 Oncology Female Switzerland Cohort study Postnatal Care medicine.medical_specialty Adolescent Population 610 Medicine & health Radiation Dosage 03 medical and health sciences Febrile seizure medicine Confidence Intervals Humans education Sweden business.industry Case-control study Cancer medicine.disease Confidence interval Risk Estimate 10036 Medical Clinic Case-Control Studies Positron-Emission Tomography business Tomography X-Ray Computed 2713 Epidemiology |
| Zdroj: | Cancer epidemiology biomarkers & prevention : a publication of the American Association for Cancer |
| ISSN: | 1538-7755 |
| Popis: | Background: Previous studies have evaluated the effect of medical diagnostic radiation on brain tumors. Recent cohort studies have reported an increased risk associated with exposure to head CT scans. Methods: Information regarding medical conditions, including prenatal and postnatal exposure to medical diagnostic radiation, was obtained from CEFALO, a multicenter case–control study performed in Denmark, Norway, Sweden, and Switzerland through face-to-face interview. Eligible cases of childhood and adolescent brain tumors (CABT) were ages 7 to 19 years, diagnosed between January 1, 2004 and August 31, 2008, and living in the participating countries (n = 352). The cases were matched by age, sex, and region to 646 population-based controls. Results: Prenatal exposure to medical diagnostic radiation and postnatal exposure to X-rays were not associated with CABTs. A higher risk estimate of CABTs, although not statistically significant, was found for exposure to head CT scan (OR, 1.86; 95% confidence interval, 0.82–4.22). The associations with head injury, febrile seizure, fever in the first 12 weeks, and general anesthesia were close to unity. Conclusions: Prenatal or postnatal medical conditions, including medical diagnostic radiation, were not associated with CABTs. On the basis of small numbers of exposed children, we observed a nonsignificant increased risk for CT scans of the head. Impact: We have presented additional evidence, suggesting that exposure to head CT scan may be associated with the occurrence of CABTs. Cancer Epidemiol Biomarkers Prev; 26(1); 110–5. ©2016 AACR. |
| Databáze: | OpenAIRE |
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