A Retrospective Study of Nail Squamous Cell Carcinoma at 2 Institutions
| Autor: | Nikki Tang, Mary E. Maloney, Ashlynne H. Clark, Nathaniel J. Jellinek |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Delayed Diagnosis Skin Neoplasms medicine.medical_treatment Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences Nail Diseases 0302 clinical medicine Risk Factors Carcinoma medicine Mohs surgery Humans Basal cell Neoplasm Metastasis Aged Retrospective Studies Aged 80 and over business.industry Retrospective cohort study Immunosuppression General Medicine Middle Aged medicine.disease Mohs Surgery medicine.anatomical_structure Nail disease 030220 oncology & carcinogenesis Nail (anatomy) Carcinoma Squamous Cell Surgery Female Neoplasm Recurrence Local business Medical literature |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 42 |
| ISSN: | 1524-4725 |
| Popis: | Squamous cell carcinoma (SCC) of the nail is infrequently reported in the medical literature and its causes are poorly understood. Studies have shown strong associations with immunosuppression, tobacco use, toxin/radiation exposure, and trauma. Common treatments include Mohs surgery and digital amputation.Review a series of nail SCCs treated at 2 institutions. Outcomes evaluated included rates of recurrence and disease progression/metastasis after treatment.A retrospective review of patients treated between 2005 and 2008. Medical record review and phone call follow-up using a standardized questionnaire were used.Forty-two tumors were identified in 34 patients. Twenty-seven patients were male (79% CI, 62%-91%) and most tumors were located on the fingernails (39/42; 91% CI, 81%-99%). Twenty-four of 39 tumors (62% CI, 45%-77%) were on the nondominant hand. The middle third finger was the most frequent digit affected (16/42). Common symptoms reported were nail dystrophy (31/42; 74% CI, 58%-86%), followed by onycholysis (22/42; 52% CI, 36%-68%). Most tumors (35/42; 83% CI, 69%-93%) were treated with Mohs surgery.Nail SCC is found nearly exclusively in adults and predominantly in men. There are multiple effective treatment possibilities including Mohs surgery, distal digital amputation, and early evidence suggesting radiotherapy. |
| Databáze: | OpenAIRE |
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