Effects of Head-Only Exposure of Rats to GSM-900 on Blood-Brain Barrier Permeability and Neuronal Degeneration
| Autor: | Gilles Ruffié, Isabelle Lagroye, Emmanuelle Haro, Philippe Lévêque, Bernard Billaudel, Florence Poulletier de Gannes, Bernard Veyret, Murielle Taxile |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Biophysics Brain damage Radiation Dosage Permeability Andrology Cresyl violet chemistry.chemical_compound medicine Animals Radiology Nuclear Medicine and imaging Neuronal degeneration Microwaves Neurons Radiation TUNEL assay Chemistry Albumin Dose-Response Relationship Radiation Environmental Exposure Anatomy Rats Inbred F344 Rats Dose–response relationship medicine.anatomical_structure Blood-Brain Barrier Permeability (electromagnetism) Neuron medicine.symptom Head Cell Phone |
| Zdroj: | Radiation Research. 172:359-367 |
| ISSN: | 1938-5404 0033-7587 |
| DOI: | 10.1667/rr1578.1 |
| Popis: | Salford et al. reported in 2003 that a single 2-h exposure to GSM-900 mobile telephony signals induced brain damage (increased permeability of the blood-brain barrier and presence of dark neurons) 50 days after exposure. In our study, 16 Fischer 344 rats (14 weeks old) were exposed head-only to the GSM-900 signal for 2 h at various brain-averaged SARs (0, 0.14 and 2.0 W/kg) or were used as cage or positive controls. Albumin leakage and neuron degeneration were evaluated 14 and 50 days after exposure. No apoptotic neurons were found 14 days after the last exposure using the TUNEL method. No statistically significant albumin leakage was observed. Neuronal degeneration, assessed using cresyl violet or the more specific marker Fluoro-Jade B, was not significantly different among the tested groups. No apoptotic neurons were detected. The findings of our study did not confirm the previous results of Salford et al. |
| Databáze: | OpenAIRE |
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