| Autor: |
Hatef Mehrabian, Rachel W. Chan, Arjun Sahgal, Hanbo Chen, Aimee Theriault, Wilfred W. Lam, Sten Myrehaug, Chia‐Lin Tseng, Zain Husain, Jay Detsky, Hany Soliman, Greg J. Stanisz |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of magnetic resonance imaging : JMRIREFERENCES. |
| ISSN: |
1522-2586 |
| Popis: |
High radiation doses of stereotactic radiosurgery (SRS) for brain metastases (BM) can increase the likelihood of radiation necrosis (RN). Advanced MRI sequences can improve the differentiation between RN and tumor progression (TP).To use saturation transfer MRI methods including chemical exchange saturation transfer (CEST) and magnetization transfer (MT) to distinguish RN from TP.Prospective cohort study.Seventy patients (median age 60; 73% females) with BM (75 lesions) post-SRS.3-T, CEST imaging using low/high-power (saturation BVoxel-wise metrics included: magnetization transfer ratio (MTR); apparent exchange-dependent relaxation (AREX); MTR asymmetry; normalized MT exchange rate and pool size product; direct water saturation peak width; and the observed Tt-Test, univariable and multivariable logistic regression, receiver operating characteristic, and area under the curve (AUC) with sensitivity/specificity values with the optimal cut point using the Youden index, Akaike information criterion (AIC), Cohen's d. P 0.05 with Bonferroni correction was considered significant.Seven metrics showed significant differences between RN and TP. The high-power MTR showed the highest AUC of 0.88, followed by low-power MTR (AUC = 0.87). The combination of low-power CEST scans improved the separation compared to individual parameters (with an AIC of 70.3 for low-power MTR/AREX). Cohen's d effect size showed that the MTR provided the largest effect sizes among all metrics.Significant differences between RN and TP were observed based on saturation transfer MRI.3 Technical Efficacy: Stage 2. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text