Association of the Rantes Gene Promoter Polymorphisms −28C/G and −403G/A with Pneumonia in Greek Children
| Autor: | Maria Hatzistilianou, Emboriadou M, Tsakiridis P, Katerina Haidopoulou, Afroditi Sakellaropoulou, Doudouliaki T, Styliani Pappa |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Chemokine Adolescent Immunology Population Inflammation Immune system Gene Frequency Risk Factors medicine Humans Immunology and Allergy Genetic Predisposition to Disease Child Promoter Regions Genetic education Chemokine CCL5 Cause of death Pharmacology education.field_of_study Polymorphism Genetic Lung Greece biology Respiratory tract infections business.industry Age Factors Infant Pneumonia medicine.disease Community-Acquired Infections Phenotype medicine.anatomical_structure Case-Control Studies Child Preschool Pneumococcal pneumonia biology.protein Female medicine.symptom business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0394-6320 |
| DOI: | 10.1177/039463201302600311 |
| Popis: | Pneumonia is an inflammation of the lung caused by microbial or viral infection. It is an important factor of morbidity for children in the developed world, as well as a frequent cause of death of children in the developing world. Chemokines are a very important part of the immune system. The purpose of this study was to investigate the role of polymorphisms of chemokine RANTES (-28C/G and-403G/A) in the development of pneumonia in children. The study included two groups of children, the patient group and the control group. The patient group consisted of 60 children, who were hospitalized with the diagnosis of pneumonia from November 2009 until May 2010. The control group consisted of 135 healthy children who had no previous history of lower respiratory tract infections. According to the results, polymorphism of chemokine RANTES -28C/G was associated to the development of pneumonia in the studied population. Polymorphism of chemokine RANTES -403G/A was not associated to the development of pneumonia in the same population. Serum levels of chemokine RANTES were lower in children who were carriers of the polymorphism -28C/G compared to children who had the normal gene type. Also, serum levels of chemokine RANTES were higher in children with pneumococcal pneumonia compared to children with pneumonia caused by other pathogens. |
| Databáze: | OpenAIRE |
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