Persistent metamorphopsia associated with branch retinal vein occlusion
| Autor: | Chieko Shiragami, Akitaka Tsujikawa, Rie Osaka, Kazuyuki Hirooka, Yukari Takasago, Saki Manabe, Koichiro Manabe, Yuki Muraoka, Yuki Nakano |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Visual acuity genetic structures Vision Visual Acuity lcsh:Medicine Social Sciences Angiogenesis Inhibitors Pathology and Laboratory Medicine Diagnostic Radiology chemistry.chemical_compound Mathematical and Statistical Techniques 0302 clinical medicine Edema Medicine and Health Sciences Psychology Prospective Studies lcsh:Science Prospective cohort study Tomography Insect Metamorphosis Multidisciplinary Radiology and Imaging Retinal detachment Middle Aged Physical Sciences Retinal Disorders Regression Analysis Female Sensory Perception Anatomy medicine.symptom Tomography Optical Coherence Statistics (Mathematics) Research Article medicine.medical_specialty Imaging Techniques Ocular Anatomy Vision Disorders Research and Analysis Methods Macular Edema 03 medical and health sciences Signs and Symptoms Ocular System Diagnostic Medicine Ranibizumab Ophthalmology Retinal Vein Occlusion medicine Humans Metamorphopsia Statistical Methods Macular edema Aged Metamorphosis business.industry lcsh:R Retinal Detachment Biology and Life Sciences Retinal Vessels Retinal medicine.disease Holometabolism 030104 developmental biology chemistry Cardiovascular Anatomy 030221 ophthalmology & optometry Eyes Blood Vessels Branch retinal vein occlusion lcsh:Q business Head Zoology Entomology Mathematics Neuroscience Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 9, p e0204015 (2018) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0204015 |
| Popis: | Purpose To investigate longitudinal changes in metamorphopsia associated with branch retinal vein occlusion. Methods In this prospective observational case series, we included 32 eyes (32 patients) with branch retinal vein occlusion and acute macular edema. Eyes were treated as needed with intravitreal ranibizumab injections for 12 months. At baseline and 1, 6, and 12 months after initiating treatment, metamorphopsia was quantified using M-CHARTS. Retinal morphology was examined through optical coherence tomography. Results Logarithm of the minimum angle of resolution visual acuity progressively improved from 0.342 ± 0.304 (Snellen equivalent: 20/44) at baseline to 0.199 ± 0.259 (20/32) and 0.118 ± 0.195 (20/26) at 1 and 12 months, respectively (both P < 0.001). The M-CHARTS score significantly decreased from 0.63 ± 0.61 at baseline to 0.45 ± 0.50 at 1 month (P = 0.044), but no further improvement was achieved with 1 year of additional treatment (6 months: 0.47 ± 0.53 [P = 0.094] and 12 months: 0.50 ± 0.44 [P = 0.173]). Three (13.6%) of 22 eyes with baseline metamorphopsia had complete metamorphopsia resolution. At 12 months, the M-CHARTS score was correlated with baseline foveal thickness (r = 0.373, P = 0.035) and the baseline M-CHARTS score (r = 0.503, P = 0.003). A multiple regression analysis revealed that only the baseline M-CHARTS score was correlated with the 12-month M-CHARTS score (β = 0.460, P = 0.027). Conclusions Eyes with branch retinal vein occlusion often have persistent metamorphopsia, even when visual acuity and retinal morphology improve. Metamorphopsia at 12 months was correlated with metamorphopsia and foveal thickness at baseline. |
| Databáze: | OpenAIRE |
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