Connecting occipital alpha band peak frequency, visual temporal resolution, and occipital GABA levels in healthy participants and hepatic encephalopathy patients
| Autor: | Julia Neugebauer, Alfons Schnitzler, Hans Jörg Wittsack, Joachim Lange, Nur Deniz Füllenbach, Gerald Kircheis, Markus Butz, Georg Oeltzschner, Dieter Häussinger, Thomas J. Baumgarten |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Magnetic Resonance Spectroscopy Visual perception genetic structures ECG Electro-cardiogram Audiology lcsh:RC346-429 HE1 Clinically manifest HE grade 1 GABA EO Eyes-open HPI Head position indication 0302 clinical medicine ICA Independent component analysis Medicine GABA+/Cr GABA-to creatine -ratio Group level Hepatic encephalopathy gamma-Aminobutyric Acid medicine.diagnostic_test Magnetoencephalography Regular Article Middle Aged Healthy Volunteers Alpha Rhythm Alpha band MRS Magnetic resonance spectroscopy Neurology Visual Perception GABAergic lcsh:R858-859.7 Female Occipital Lobe HE Hepatic encephalopathy medicine.medical_specialty MNI Montreal Neurological Institute Cognitive Neuroscience lcsh:Computer applications to medicine. Medical informatics Alpha oscillations 03 medical and health sciences MEG Magnetoencephalography Humans Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Aged business.industry CSD Cross-spectral density Neurophysiology medicine.disease EOG Electro-oculogram 030104 developmental biology EC Eyes-closed Temporal resolution CFF Critical flicker frequency Neurology (clinical) mHE Minimal HE business GABA γ-aminobutyric acid Peak frequency Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 20, Iss, Pp 347-356 (2018) NeuroImage: Clinical NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Recent studies have proposed a connection between the individual alpha band peak frequency and the temporal resolution of visual perception in healthy human participants. This connection rests on animal studies describing oscillations in the alpha band as a mode of phasic thalamocortical information transfer for low-level visual stimuli, which critically relies on GABAergic interneurons. Here, we investigated the interplay of these parameters by measuring occipital alpha band peak frequency by means of magnetoencephalography, visual temporal resolution by means of behavioral testing, and occipital GABA levels by means of magnetic resonance spectroscopy. Importantly, we investigated a sample of healthy participants and patients with varying grades of hepatic encephalopathy, which are known to exhibit decreases in the investigated parameters, thus providing an increased parameter space. We found that occipital alpha band peak frequency and visual temporal resolution were positively correlated, i.e., higher occipital alpha band peak frequencies were on average related to a higher temporal resolution. Likewise, occipital alpha band peak frequency correlated positively with occipital GABA levels. However, correlations were significant only when both healthy participants and patients were included in the analysis, thereby indicating a connection of the measures on group level (instead of the individual level). These findings provide new insights into neurophysiological and neurochemical underpinnings of visual perception. Highlights • Occipital alpha peak frequencies are decreased in HE patients. • Occipital alpha peak frequencies are positively related to visual temporal resolution. • Occipital alpha peak frequencies are positively related to occipital GABA levels. • Correlations were only found across groups, but not within groups. |
| Databáze: | OpenAIRE |
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