Comparison of two tourniquet application times for regional intravenous limb perfusions with amikacin in sedated or anesthetized horses
| Autor: | Jorge E. Nieto, Fabio A Aristizabal, B. Morales, Alonso G. P. Guedes, Jack R. Snyder, Julie E. Dechant, S. Yamout |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Time Factors 040301 veterinary sciences 030106 microbiology Metacarpophalangeal Joint 0403 veterinary science Random Allocation 03 medical and health sciences Pneumatic tourniquet Pharmacokinetics Forelimb Synovial Fluid Limb perfusion medicine Animals Synovial fluid Horses Amikacin Standing sedation Tourniquet application Tourniquet Carpal Joints General Veterinary business.industry 04 agricultural and veterinary sciences Tourniquets Anti-Bacterial Agents Surgery Perfusion Anesthesia Administration Intravenous Female Animal Science and Zoology business medicine.drug |
| Zdroj: | The Veterinary Journal. 208:50-54 |
| ISSN: | 1090-0233 |
| Popis: | Regional limb perfusion (RLP) in horses has proven to be a simple and effective technique for the treatment of synovial and musculoskeletal infections in the distal portion of the limbs. The ideal tourniquet time needed to achieve therapeutic synovial concentrations remains unknown. The pharmacokinetic effects of general anesthesia (GA) versus standing sedation (SS) RLP on synovial amikacin concentrations are not completely understood. This study investigated the pharmacokinetic effects of RLP under general anesthesia (GA) versus standing sedation (SS) on synovial amikacin concentration following 20 or 30 min tourniquet time. Using 1 g of amikacin RLP was performed in two groups of six horses (GA and SS). A pneumatic tourniquet was applied proximal to the carpus and maintained for 20 or 30 min. Two weeks later, the opposite treatment (20 or 30 min) was randomly performed in the opposite limb of horses in each group (GA and SS). Synovial fluid samples were collected from the metacarpophalangeal (MCP) and radiocarpal (RC) joints. Amikacin was quantified by a fluorescence polarization immunoassay. Regardless of the group, no significant difference in the synovial amikacin concentrations was noted between 20 and 30 min RLP. Mean synovial concentrations of amikacin in the standing sedated horses were significantly higher in the MCP joint at 30 min (P = 0.003) compared to horses under general anesthesia. No significant difference was noted for the RC joint. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect