Nitric oxide (NO) and nanoparticles – Potential small tools for the war against COVID-19 and other human coronavirus infections

Autor: Amedea B. Seabra, Joana C. Pieretti, Olga Rubilar, Gonzalo Tortella, Richard Weller
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Cancer Research
Coronavirus disease 2019 (COVID-19)
NOx
Nitrogen Reactive Species
Potential candidate
SARS-CoV-2
Severe Acute Respiratory Syndrome Corona Virus 2
Review
Biology
Bioinformatics
Nitric Oxide
Antiviral Agents
WHO
World Health Organization
Nitric oxide
No donors
03 medical and health sciences
chemistry.chemical_compound
Drug Delivery Systems
Virology
Administration
Inhalation
Humans
In patient
RNA
Ribonucleic acid
Antiviral
030304 developmental biology
No release
ComputingMethodologies_COMPUTERGRAPHICS
0303 health sciences
O2•-
Superoxide
030306 microbiology
FDA
US Food and Drug Administration
AgNPs
Silver Nanoparticles
COVID-19
SARS-CoV
Clot formation
Human coronavirus
NO
Nitric Oxide
UVA
Ultraviolet radiation A
COVID-19 Drug Treatment
iNOS
Inducible NO Synthase
ONOO-
Peroxynitrite
Infectious Diseases
chemistry
IDO
Indoleamine 2
3–dioxygenase
Nanoparticles
SNAP
S-nitroso-N-acetylpenicillamine
CuNPs
Copper Nanoparticles
Coronavirus Infections
Inhaled nitric oxide
Zdroj: Virus Research
Pieretti, J C, Rubilar, O, Weller, R B, Tortella, G R & Seabra, A B 2020, ' Nitric oxide (NO) and nanoparticles – Potential small tools for the war against COVID-19 and other human coronavirus infections ', Virus Research, vol. 291, pp. 198202 . https://doi.org/10.1016/j.virusres.2020.198202
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2020.198202
Popis: Graphical abstract
Highlights • Nitric oxide has shown antiviral potential against respiratory viral infections. • Protocols of inhaled nitric oxide against COVID-19 are in current trial. • Current trials might indicate suitable parameters for nitric oxide treatment against COVID-19. • Nitric oxide allied to nanoparticles may improve the antiviral potential.
The endogenous free radical nitric oxide (NO) plays a pivotal role in the immunological system. NO has already been reported as a potential candidate for use in the treatment of human coronavirus infections, including COVID-19. In fact, inhaled NO has been used in clinical settings for its antiviral respiratory action, and in the regulation of blood pressure to avoid clot formation. In this mini-review, we discuss recent progress concerning the antivirus activity of NO in clinical, pre-clinical and research settings, and its beneficial effects in the treatment of clinical complications in patients infected with coronaviruses and other respiratory viral diseases, including COVID-19. We also highlight promising therapeutic effects of NO donors allied to nanomaterials to combat COVID-19 and other human coronavirus infections. Nanomaterials can be designed to deliver sustained, localized NO release directly at the desired application site, enhancing the beneficial effects of NO and minimizing the side effects. Challenges and perspectives are presented to open new fields of research.
Databáze: OpenAIRE
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