Etiology of hepatocellular carcinoma in Latin America: a prospective, multicenter, international study
| Autor: | Francisco Carlos de Souza, Rodrigo Zapata, Joao Galizzi, Angelo Alves de Mattos, Carlos Miguez, Nelia Hernández, Solangel Díaz, Catalina Santa, María Elisa Reig, Yamila Martínez Artola, Ezequiel Ridruejo, Eduardo Fassio, Leonardo Pinchuk |
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| Předmět: |
Male
medicine.medical_specialty Alcoholic liver disease Cryptogenic cirrhosis Cirrhosis Carcinoma Hepatocellular International Cooperation Specialties of internal medicine Liver disease Interquartile range Liver Cirrhosis Alcoholic Internal medicine medicine Humans Prospective Studies Prospective cohort study Aged Retrospective Studies Hepatology business.industry Incidence Liver Neoplasms BCLC staging system General Medicine Hepatitis C Hepatitis B Middle Aged medicine.disease Surgery Alcoholic cirrhosis Latin America RC581-951 Hepatocellular carcinoma Chronic Disease Female business |
| Zdroj: | Europe PubMed Central Scopus-Elsevier Annals of Hepatology, Vol 9, Iss 1, Pp 63-69 (2010) |
| Popis: | Background/aims. No prospective study has been published investigating etiology of HCC in Latin America. The primary aim of this prospective study was to analyze the etiology of liver disease in patients with HCC from our area. Secondary aims were to evaluate staging using Okuda and BCLC classifications; and percentage of patients receiving treatment. Methods. The Governing Board of the Latin American Association for the Study of the Liver designed the protocol. During a 18 month period, all members were invited to load their incident HCC cases on line. Results. 240 cases from 9 countries were uploaded, 174 were male (72.5%), median age was 64 years, interquartile range 57-72. In 85.4% of cases, patients had underlying cirrhosis. Main etiological factors were: HCV in 74 patients (30.8%), alcohol in 49 (20.4%), cryptogenic cirrhosis in 35 (14.6%), HBV in 26 (10.8%), HCV plus alcohol in 14 (5.8%). Considering the combinations, hepatitis C was shown in 91 patients (38%); chronic alcoholism in 68 patients (28%); and hepatitis B in 33 patients (14%). There were no significant differences between the groups in the age at diagnosis. Percentage of male gender was higher in groups of alcohol (94%), HCV plus alcohol (93%) and HBV (85%) than in cryptogenic cirrhosis (60%) and HCV (59%) (p |
| Databáze: | OpenAIRE |
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