An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
| Autor: | Alexander Y. Rudensky, Yuqiong Liang, Ye Zheng, Chyi-Song Hsieh, Jason D. Fontenot |
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| Rok vydání: | 2006 |
| Předmět: |
animal structures
T-Lymphocytes Molecular Sequence Data Immunology T cell immunology Receptors Antigen T-Cell Autoimmunity Mice Transgenic Thymus Gland Biology Polymerase Chain Reaction T-Lymphocytes Regulatory Mice Intersection T-Lymphocyte Subsets Animals Immunology and Allergy Cytotoxic T cell Amino Acid Sequence IL-2 receptor Receptor Gene Library Mice Knockout Genetics Extramural T-cell receptor Forkhead Transcription Factors Sequence Analysis DNA Specific Pathogen-Free Organisms Cell biology Mice Inbred C57BL |
| Zdroj: | Nature Immunology. 7:401-410 |
| ISSN: | 1529-2916 1529-2908 |
| Popis: | The relationship between the T cell receptor (TCR) repertoires used by self-reactive transcription factor Foxp3-positive (Foxp3(+)) CD4(+) regulatory T cells (T(reg) cells) and nonregulatory T cells with autoimmune potential is unclear. Here we found that the TCR repertoire of thymic T(reg) cells in TCRbeta-transgenic mice was diverse and was more similar to that of peripheral T(reg) cells than that of nonregulatory T cells, suggesting that thymic T(reg) cells make a substantial contribution to the peripheral T(reg) cell population. Activated T cells in Foxp3-deficient mice, which lack T(reg) cells, 'preferentially' used TCRs found in the TCR repertoire of T(reg) cells in Foxp3-sufficient TCRbeta-transgenic mice, suggesting that these self-reactive TCRs contribute to the pathology of Foxp3-deficient mice. Our analyses suggest that T(reg) cells and potentially pathogenic autoimmune T cells use overlapping pools of self-reactive TCRs. |
| Databáze: | OpenAIRE |
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