The IgG Fc receptor, FcγRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma
| Autor: | Patricia Le Baccon, Pascal Mossuz, Rifat Hamoudi, Christian Bastard, Gustav Klobeck, Dominique Leroux, Jean Jacques Sotto, Ruth Rimokh, Mary Callanan, Martin J. S. Dyer, Samuel Duley |
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| Rok vydání: | 2000 |
| Předmět: |
Lymphoma
Chromosomes Human Pair 22 Molecular Sequence Data Fc receptor Follicular lymphoma Mice Nude Chromosomal translocation FCGR2B Translocation Genetic Mice Antigen Antigens CD Tumor Cells Cultured medicine Animals Humans RNA Messenger Cloning Molecular Receptor In Situ Hybridization Fluorescence Multidisciplinary Base Sequence biology Receptors IgG Biological Sciences Flow Cytometry medicine.disease Molecular biology Gene Expression Regulation Neoplastic Chromosomes Human Pair 1 Tumor progression biology.protein |
| Zdroj: | Proceedings of the National Academy of Sciences. 97:309-314 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.97.1.309 |
| Popis: | Rearrangement of chromosomal bands 1q21–23 is one of the most frequent chromosomal aberrations observed in hematological malignancy. The genes affected by these rearrangements remain poorly characterized. Typically, 1q21–23 rearrangements arise during tumor evolution and accompany disease-specific chromosomal rearrangements such as t(14;18) (BCL2) and t(8;14) (MYC), where they are thus thought to play an important role in tumor progression. The pathogenetic basis of this 1q21–23-associated disease progression is currently unknown. In this setting, we surveyed our series of follicular lymphoma for evidence of recurring 1q21–23 breaks and identified three cases in which a t(14;18)(q32;q21) was accompanied by a novel balanced t(1;22)(q22;q11). Molecular cloning of the t(1;22) in a cell line (B593) derived from one of these cases and detailed fluorescentin situhybridization mapping in the two remaining cases identified theFCGR2Bgene, which encodes the immunoreceptor tyrosine-based inhibition motif-bearing IgG Fc receptor, FcγRIIB, as the target gene of the t(1;22)(q22;q11). We demonstrate deregulation ofFCGR2Bleading to hyperexpression of FcγRIIb2 as the principal consequence of the t(1;22). This is evidence that IgG Fc receptors can be targets for deregulation through chromosomal translocation in lymphoma. It suggests that dysregulation ofFCGR2Bmay play a role in tumor progression in follicular lymphoma. |
| Databáze: | OpenAIRE |
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