Ketogenic diet guidelines for infants with refractory epilepsy
| Autor: | Anastasia Dressler, Magdalena Dudzińska, Laura Dority, Stéphane Auvin, Elizabeth G Neal, Georgiana Fitzsimmon, Joerg Klepper, Elles J.T.M. van der Louw, Maddelena Marchió, J. Helen Cross, Bärbel Leiendecker, Dorine A. M. van den Hurk, Lindsey M Thompson |
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| Přispěvatelé: | Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.medical_treatment Alternative medicine Medizin Clinical Neurology Review Guidelines 03 medical and health sciences Epilepsy 0302 clinical medicine 030225 pediatrics medicine Journal Article Humans Pediatrics Perinatology and Child Health Adverse effect Project group Refractory epilepsy business.industry Disease Management Infant General Medicine Seizure freedom Ketogenic diet medicine.disease Perinatology Discontinuation and Child Health Treatment Outcome Pediatrics Perinatology and Child Health Neurology (clinical) business Diet Ketogenic 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Paediatric Neurology, 20(6), 798-809. W.B. Saunders European Journal of Paediatric Neurology, 20(6), 798. W.B. Saunders Ltd |
| ISSN: | 1090-3798 |
| Popis: | Background The ketogenic diet (KD) is an established, effective non-pharmacologic treatment for drug resistant childhood epilepsy. For a long time, the KD was not recommended for use in infancy (under the age of 2 years) because this is such a crucial period in development and the perceived high risk of nutritional inadequacies. Indeed, infants are a vulnerable population with specific nutritional requirements. But current research shows that the KD is highly effective and well tolerated in infants with epilepsy. Seizure freedom is often achieved and maintained in this specific patient group. There is a need for standardised protocols and management recommendations for clinical use. Method In April 2015, a project group of 5 experts was established in order to create a consensus statement regarding the clinical management of the KD in infants. The manuscript was reviewed and amended by a larger group of 10 international experts in the KD field. Consensus was reached with regard to guidance on how the diet should be administered and in whom. Results The resulting recommendations include patient selection, pre-KD counseling and evaluation, specific nutritional requirements, preferred initiation, monitoring of adverse effects at initiation and follow-up, evaluation and KD discontinuation. Conclusion This paper highlights recommendations based on best evidence, combined with expert opinions and gives directions for future research. |
| Databáze: | OpenAIRE |
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