Effects of delta9-tetrahydrocannabinol on hamster fetuses
| Autor: | Joneja Mg |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Statistical difference Hamster Gestational Age Toxicology Animal science Fetus Pregnancy Internal medicine Cricetinae mental disorders medicine Animals Dronabinol Tetrahydrocannabinol Intubation Gastrointestinal Maternal-Fetal Exchange Syrian hamsters Growth retardation Mesocricetus business.industry organic chemicals Abnormalities Drug-Induced Pollution Endocrinology Gestation Female business Olive oil medicine.drug |
| Zdroj: | Journal of toxicology and environmental health. 2(5) |
| ISSN: | 0098-4108 |
| Popis: | Pregnant golden Syrian hamsters were given single or multiple intragastric doses of Δ9‐tetrahydrocannabinol (Δ9‐THC) dissolved in olive oil. Dose levels of 125, 250, or 500 mg/kg were administered by gavage once during gestational days 7–12 and of 25, 50, or 100 mg/kg daily on days 7–10, 9–12, or 7–12 in the two experimental series. Untreated and vehicle‐injected controls were used for each series. All fetuses were examined on day 15 of gestation. Larger doses of Δ9‐THC induced a high frequency of fetal mortality and growth retardation. Vehicle‐injected controls showed up to 3% fetuses with external anomalies and several Δ9‐THC treated samples had higher frequencies, ranging up to 7%, but a majority of the samples did not show any statistical difference between the Δ9‐THC treated and corresponding control groups. However, a single dose of 500 mg/kg Δ9‐THC given on day 10 and four daily doses of 100 mg/kg Δ9‐THC on days 7–10 produced significantly higher frequencies (p < 0.05) of external anomalies, 5.36% ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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