Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
| Autor: | Mark J. Kurth, Young-Dae Gong, Aizhan Abdildinova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Scaffold
solid-phase synthesis Peptidomimetic Pharmaceutical Science Review 010402 general chemistry 01 natural sciences Pharmacy and materia medica Solid-phase synthesis Biological property Drug Discovery Rapid access 010405 organic chemistry Chemistry Pharmacology and Pharmaceutical Sciences protein secondary structure mimetics Combinatorial chemistry Small molecule 0104 chemical sciences RS1-441 solid-phase peptide synthesis strategies peptidomimetic synthesis peptidomimetics Medicine Molecular Medicine Pharmacophore |
| Zdroj: | Pharmaceuticals (Basel, Switzerland), vol 14, iss 5 Pharmaceuticals Pharmaceuticals, Vol 14, Iss 449, p 449 (2021) |
| ISSN: | 1424-8247 |
| DOI: | 10.3390/ph14050449 |
| Popis: | Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and also is widely used for the synthesis of peptidomimetics. Small molecules including heterocycles serve as a core for hundreds of drugs, including peptidomimetic molecules. This review covers solid-phase synthesis strategies for peptidomimetics molecules based on heterocycles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|