Ovarian antibodies detected by immobilized antigen immunoassay in patients with premature ovarian failure
| Autor: | B. Caldwell, T. Asari, Stephen P. Boyers, Alan H. DeCherney, I. Visintin, Judith L. Luborsky |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases medicine.drug_class Endocrinology Diabetes and Metabolism Placenta Clinical Biochemistry Thyroid Gland Ovary Enzyme-Linked Immunosorbent Assay Biology Biochemistry Methylprednisolone Antibodies Endocrinology Antigen Internal medicine medicine Humans In patient Ovarian Diseases Ovum medicine.diagnostic_test business.industry Biochemistry (medical) Autoantibody Obstetrics and Gynecology General Medicine Luteinizing Hormone Middle Aged medicine.disease Immunohistochemistry female genital diseases and pregnancy complications Premature ovarian failure medicine.anatomical_structure Immunoassay Immunology biology.protein Female Gonadotropin Antibody Follicle Stimulating Hormone business Infertility Female |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 70(1) |
| ISSN: | 0021-972X |
| Popis: | An enzyme-linked immunosorbent assay (ELISA) was used to detect ovarian and oocyte antibodies in serum from 45 patients with premature ovarian failure (POF). Control sera were obtained from a similar group of normally cycling women without POF. A specific antibody reaction was found when POF sera were tested against human ovary (47%) or oocytes (47%). A combined total of 69% of the sera were positive for either ovary or oocytes. Fewer sera were positive for antibodies against human thyroid (18%) or human placenta (22%), and virtually no reaction with human liver (4%) was seen. LH antibodies were detected by ELISA against LH in only 3 POF sera that also contained ovarian antibodies. Therefore, gonadotropin antibodies alone do not appear to account for POF. In addition, 2 patients were treated by immunosuppression and became pregnant coincident with a decline in the serum concentration of ovarian antibodies. In summary, the results of this study are consistent with previous immunohistochemical data which indicate that ovarian and oocyte antibodies are common in patients with POF. This supports the concept that some forms of POF are associated with an autoimmune process. Furthermore, detection of ovarian and oocyte antibodies by ELISA may permit routine diagnosis of autoimmune POF and provide a basis for therapy. |
| Databáze: | OpenAIRE |
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