Prognostic value of the location of submucosal uterine leiomyomas in infertility
| Autor: | Mihai Dimitriu, Liana Pleș, Florin Daniel Călin, Cringu Antoniu Ionescu, George-Alexandru Roșu, Dan-Bogdan Navolan, Alexandra Matei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Infertility
Cancer Research medicine.medical_specialty Pregnancy business.industry Obstetrics Uterine fibroids Early Pregnancy Loss media_common.quotation_subject Reproductive medicine Fertility General Medicine Articles medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure Immunology and Microbiology (miscellaneous) Obstetrics and gynaecology medicine Uterine cavity business media_common |
| Zdroj: | Exp Ther Med |
| Popis: | Submucosal fibroid location and size are predictive factors of impaired fertility. Submucosal fibroids cause infertility through several mechanisms including distortion of the endometrial cavity, increased uterine contractility, local inflammation and remodeling of the endometrial blood supply. This is a monocentric, retrospective, cross-sectional study, conducted in the Department of Obstetrics and Gynecology of 'Sf. Pantelimon' Clinical Emergency Hospital, analyzing patients from a 5-year period (January 2015-December 2019). In the present study, the relationship between different characteristics of the submucosal fibroids (among others, location and dimensions) and fertility (birth rates, early pregnancy loss rates) were investigated. This study identified that submucosal and intramural fibroids are risk factors for reduced birth rate compared with subserosal fibroids (P=0.02, RR=2.58, 95% CI 1.03-6.47; P=0.005, RR=1.18, 95% CI 1.02-1.35, respectively). In addition, G2 leiomyomas are risk factors for low birth rate compared with G0 and G1 fibroids (P=0.01, RR=1.95, 95% CI 1.05-3.60). Moreover, the presence of a subserosal fibroid was associated with an increased early pregnancy loss rate (P=0.01, RR=2.14, 95% CI 1.05-4.35). In conclusion, the location and degree of uterine cavity distortion are important factors that alter the normal development of a pregnancy and the birth rate. |
| Databáze: | OpenAIRE |
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