Chemical and Biological Properties of an Arabinogalactan from Phyllanthus niruri

4)-linked beta-Galp main chain, substituted by rhamnose, galacturonic acid, arabinose, xylose, galactose, and glucose-containing side chains, with nonreducing end-units of arabinofuranose, xylopyranose, galactopyranose, and glucopyranose. In immunological studies, the arabinogalactan stimulated superoxide anion production, when tested using peritoneal macrophages of mice, but did not interfere with the nitric oxide pathway. Thus, traditional aqueous extraction methods, such as decoction and infusion, provide a major polysaccharide, which stimulates an intense biological response in macrophages: this could represent an interesting approach in phytotherapeutic treatments. -->

ISSN:	1520-6025 0163-3864
DOI:	10.1021/np050129s
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afa940fd507500d1cb30edd9e752529 https://doi.org/10.1021/np050129s
Přírůstkové číslo:	edsair.doi.dedup.....3afa940fd507500d1cb30edd9e752529
Autor:	Thales R. Cipriani, Elaine R. Carbonero, Philip A.J. Gorin, Guilhermina Rodrigues Noleto, Caroline G. Mellinger, Maria Benigna M. Oliveira, Marcello Iacomini
Rok vydání:	2005
Předmět:	Arabinose Phyllanthus Rhamnose Stereochemistry Pharmaceutical Science Uronic acid Xylose Nitric Oxide Polysaccharide Galactans Analytical Chemistry Mice chemistry.chemical_compound Polysaccharides Superoxides Arabinogalactan Drug Discovery Animals Nuclear Magnetic Resonance Biomolecular Pharmacology chemistry.chemical_classification Plants Medicinal Molecular Structure biology Macrophages Organic Chemistry biology.organism_classification Complementary and alternative medicine chemistry Biochemistry Galactose Molecular Medicine
Zdroj:	Journal of Natural Products. 68:1479-1483
ISSN:	1520-6025 0163-3864
DOI:	10.1021/np050129s
Popis:	Phyllanthus niruri is a well-known herb widely used medicinally in Asia, Africa, and South America. Aqueous extraction of the intact plant provided an acidic arabinogalactan, which was characterized chemically, and its effects on peritoneal macrophage activation were determined. Methylation analyses and (13)C NMR spectroscopy showed it to have a complex structure with a (1-->4)-linked beta-Galp main chain, substituted by rhamnose, galacturonic acid, arabinose, xylose, galactose, and glucose-containing side chains, with nonreducing end-units of arabinofuranose, xylopyranose, galactopyranose, and glucopyranose. In immunological studies, the arabinogalactan stimulated superoxide anion production, when tested using peritoneal macrophages of mice, but did not interfere with the nitric oxide pathway. Thus, traditional aqueous extraction methods, such as decoction and infusion, provide a major polysaccharide, which stimulates an intense biological response in macrophages: this could represent an interesting approach in phytotherapeutic treatments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afa940fd507500d1cb30edd9e752529 https://doi.org/10.1021/np050129s Zobrazit plný text záznamu