Pharmacokinetic Profile of Spectrum Reduced Nicotine Cigarettes
| Autor: | Neil Trushin, Nayantara Singh, Helen M. Kamens, Jonathan Foulds, Steven A. Branstetter, Dongxiao Sun, Joseph J Sipko, Joshua E. Muscat, Carley N. Miller, Russell T. Nye, John P. Richie, Constanza P. Silva |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Nicotine Adolescent Subjective effects media_common.quotation_subject Original Investigations Pharmacology Cigarette Smoking Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Pharmacokinetics Nicotine concentration Humans Medicine 030212 general & internal medicine media_common Smoke Carbon Monoxide Extramural business.industry Public Health Environmental and Occupational Health Tobacco Products Middle Aged Abstinence Regulatory policy Female Smoking Cessation business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Nicotine Tob Res |
| ISSN: | 1469-994X 1462-2203 |
| Popis: | Introduction Spectrum research cigarettes have been developed with varying nicotine content for use in studies evaluating the effects of a regulatory policy reducing the permissible nicotine content in cigarettes. This study aimed to characterize the nicotine pharmacokinetic profile of Spectrum cigarettes. Methods Twelve daily smokers attended four sessions and had blood nicotine, exhaled carbon monoxide, and subjective effects measured before and after smoking either a single cigarette of their preferred brand or high (10.9 mg/cigarette), medium (3.2 mg/cigarette), or low (0.2 mg/cigarette) nicotine content Spectrum research cigarettes, in a double-blind design with order counterbalanced. Results The boost in blood nicotine concentration was dose-dependent, with a boost of 0.3, 3.9, and 17.3 ng/mL for low-, medium-, and high-nicotine content Spectrum cigarettes. The high dose Spectrum had a similar nicotine boost to the “preferred brand” cigarettes (19 ng/mL). Subjects took longer puffs on the low nicotine cigarettes, but smoked these cigarettes faster than other cigarette types. High nicotine Spectrum cigarettes reduced the urge to smoke more than other cigarette types. Conclusions This study shows that Spectrum research cigarettes produce blood nicotine absorption in a dose-dependent manner, and therefore, are appropriate for use in studies of nicotine reduction in cigarettes. Implications This is the first study to determine the pharmacokinetic profile of Spectrum reduced nicotine content research cigarettes following an overnight abstinence. These data could provide evidence to regulatory agencies about the effects of reduced nicotine cigarettes when considering regulations on tobacco reduction. |
| Databáze: | OpenAIRE |
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