Association of vitamin B12 mediated hyperhomocysteinemia and methylenetetrafolate reductase (C677T) gene polymorphism with cognitive impairment: A population based study from North India
| Autor: | Kallur Nava Saraswathy, Rajan Gaur, Suniti Yadav, Gurjinder Kaur |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Hyperhomocysteinemia medicine.medical_specialty Homocysteine Population India Comorbidity Reductase Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Folic Acid Internal medicine Genotype medicine Humans Cognitive Dysfunction 030212 general & internal medicine Vitamin B12 Allele education Biological Psychiatry Methylenetetrahydrofolate Reductase (NADPH2) Aged education.field_of_study business.industry Middle Aged medicine.disease Psychiatry and Mental health Vitamin B 12 chemistry Female Gene polymorphism business 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry research. 270 |
| ISSN: | 1872-7123 |
| Popis: | The present study attempts to understand the association of homocysteine, vitamin B12, folate, and MTHFR C677T gene polymorphism with cognitive impairment (CI) among 808 individuals of either sex (aged 30–70 years) from a largely vegetarian, mendelian population of North India. Biochemical and genetic analyses were done using standard protocols. Results indicate that 34.3% of the subjects had mild CI, 28.7% moderate CI and 0.2% were having severe CI. Hyperhomocysteinemia was found to be a significant risk factor for moderate/severe CI. Both CT genotype and T allele of MTHFR C677T gene polymorphism were found to pose significant decreased risk for CI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect