Regional brain perfusion in 12 cats measured with technetium-99m-ethyl cysteinate dimer pinhole single photon emission computed tomography (SPECT)
Autor: | Kathelijne Peremans, André Dobbeleir, Hendrik de Leeuw, Vincent O. Boer, Myriam Hesta, Tim Waelbers, Simon Vermeire, Koen Piron, Maarten A. D. Vente, Ingeborgh Polis |
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Rok vydání: | 2012 |
Předmět: |
Male
Tomography Emission-Computed Single-Photon Temporal cortex medicine.diagnostic_test business.industry Brain Perfusion scanning Magnetic resonance imaging Organotechnetium Compounds Single-photon emission computed tomography law.invention Cerebral blood flow law Cats Animals Medicine Female Cysteine Small Animals business Nuclear medicine Perfusion Technetium-99m Gamma camera |
Zdroj: | Journal of Feline Medicine and Surgery. 15:105-110 |
ISSN: | 1532-2750 1098-612X |
Popis: | With the use of perfusion tracers, in vivo examination of the regional cerebral blood flow in cats can be performed with single photon emission computed tomography (SPECT). Reliable perfusion data of normal, healthy cats are necessary for future clinical studies or other research use. Therefore, this dataset of the regional perfusion pattern of the normal feline brain was created. Twelve cats were used in this study. Technetium-99m-ethyl cysteinate dimer (99mTc-ECD) was injected intravenously and the acquisition, using a triple head gamma camera equipped with three multi-pinhole collimators (pinhole SPECT), was started 40 mins after tracer administration under general anaesthesia. Nineteen regions of interest were defined using 7T magnetic resonance images of the feline brain and a topographical atlas. Regional counts were normalised to the counts of two reference regions: the total brain and the cerebellum. The highest tracer uptake was noticed in the subcortical structures, and the lowest in the frontal cortex and the cerebellum. Also left–right asymmetry in the temporal cortex and a rostrocaudal gradient of 5% were observed. |
Databáze: | OpenAIRE |
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