Novel tamarind seed gum-alginate based multi-particulates for sustained release of dalfampridine using response surface methodology
| Autor: | Jyosna Doniparthi, Jeevana Jyothi. B |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Central composite design Alginates Surface Properties Chemistry Pharmaceutical 02 engineering and technology Tamarind seed Biochemistry Diffusion 03 medical and health sciences Differential scanning calorimetry Structural Biology Polymer ratio Plant Gums Tamarindus Response surface methodology 4-Aminopyridine Particle Size Fourier transform infrared spectroscopy Molecular Biology 030304 developmental biology Drug Carriers 0303 health sciences Hydrogels General Medicine 021001 nanoscience & nanotechnology Controlled release Microspheres Drug Liberation Kinetics Models Chemical Chemical engineering Delayed-Action Preparations Seeds Particle size 0210 nano-technology |
| Zdroj: | International Journal of Biological Macromolecules. 144:725-741 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2019.11.203 |
| Popis: | The current study involves development of novel tamarind seed gum - alginate complex microspheres for sustained release of dalfampridine by using Central Composite design in combination with response surface methodology. Polymer ratio (A), agitation speed (B) and concentration of CaCl2 (C) were selected as independent variables. Dalfampridine loaded microspheres are prepared by ionotropic gelation technique and were evaluated for responses. The software numerical optimization process, surface and contour plots predicted the level of independent variables A, B and C (2.6, 800.412 rpm and 1.1%w/w respectively), for maximum response of drug entrapment efficiency (86.09%), controlled release of drug at 1 h, 6 h, 12 h (29.84%, 67.92%, 86.42%) and optimized particle size (613.212 μm) respectively. Low magnitude of relative error for the optimized formulation confirms the validation of model. Optimized formulation was characterized for compatibility by Fourier Transform infrared spectroscopy and Differential scanning calorimetry. The drug release data was best fitted by first order and Higuchi square root model with non-Fickian diffusion kinetics. Therefore, such an attempt of fabrication of dalfampridine multi-particulates system by using tamarind seed gum and sodium alginate may be useful in a better way, for sustaining the release of drug over 12 h. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect