Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model
| Autor: | Anuoluwapo J. Salemcity, Ese Ogugu Siemuri, Jacob K. Akintunde |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Calliandra Antioxidant Physiology medicine.medical_treatment Ascorbic Acid Pharmacology Kidney Nitric Oxide Plant Roots Antioxidants Lipid peroxidation chemistry.chemical_compound Inhibitory Concentration 50 Therapeutic index Malondialdehyde Drug Discovery Botany Hydroxides Medicine Animals Rats Wistar IC50 biology Dose-Response Relationship Drug business.industry Plant Extracts Fabaceae General Medicine Free Radical Scavengers biology.organism_classification Ascorbic acid Rats Disease Models Animal chemistry Liver visual_art visual_art.visual_art_medium Bark Lipid Peroxidation business |
| Zdroj: | Journal of basic and clinical physiology and pharmacology. 26(4) |
| ISSN: | 2191-0286 |
| Popis: | The attendant side effects associated with some synthetic drugs used in the management of diseases have led to the search for safer alternative therapies that are relatively cheaper with minimal side effects.The methanol extract of Calliandra portoricensis root bark (CPRB) was orally administered at the doses of 5, 10, 20, and 25 mg/kg body weight for 14 consecutive days of 5 rats in each group. The control rats were given distilled water.The 95% methanol extract of CPRB significantly (p0.05) scavenged NO• and OH• radicals compared to vitamin C. The level of lipid peroxidative products (malondialdehyde, MDA) was significantly (p0.05) attenuated in a dose-dependent manner. Antioxidant enzymes including superoxide dismutase and catalase were significantly (p0.05) exercabated in both liver and kidney in a dose-dependent manner. Furthermore, serum AST, alanine aminotransaminase and γ-glutamyltransferase (GGT) activity depicted non-significant (p0.05) increase in the treated animals. The histological examination showed mild vacuolar, portal congestion and cell infiltration by mononuclear of the hepatic tissues.The study then concluded that a therapeutic dose of the methanol extract of CPRB triggered the antioxidant defence systems in male rats. It is, therefore, recommended that the doses should be carefully and clinically chosen because higher doses may cause some health risks. |
| Databáze: | OpenAIRE |
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