An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source
| Autor: | Shannon L. Turvey, Taya Forde, Ameeta E. Singh, Fabien Mavrot, Susan J. Kutz, Michael Groeschel, A. Mark Joffe, Prenilla Naidu, Catherine Hui |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Canada Prosthetic joint infection medicine.medical_specialty Prosthesis-Related Infections food.ingredient Erysipeloid medicine.drug_class 030106 microbiology Antibiotics Animals Wild Case Report Erysipelothrix rhusiopathiae lcsh:Infectious and parasitic diseases Microbiology Erysipelothrix Infections 03 medical and health sciences 0302 clinical medicine Erysipelothrix food Medical microbiology Zoonoses medicine Animals Humans lcsh:RC109-216 030212 general & internal medicine Aged Arthritis Infectious Whole Genome Sequencing biology Arctic Regions business.industry Amoxicillin medicine.disease biology.organism_classification 3. Good health Infectious Diseases Parasitology Septic arthritis Female Knee Prosthesis business medicine.drug |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-7 (2019) |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/s12879-019-3913-7 |
| Popis: | Background: \ud Erysipelothrix rhusiopathiae is a zoonotic pathogen that causes erysipeloid and is most frequently associated with exposure to domestic swine. Infection of native and prosthetic joints is a rarely reported manifestation.\ud \ud Case presentation: \ud We describe a case of E. rhusiopathiae prosthetic joint infection in a woman with a history of exposure to wild animals in the Canadian Arctic. Patient management involved a 1-stage surgical revision exchange with an antibiotic impregnated cement spacer and 6 weeks of intravenous penicillin G followed by 6 weeks of oral amoxicillin. Ten previously reported cases of E. rhusiopathiae joint infection are reviewed. Recent increases in mortality due to infection with this organism among host animal populations in the Canadian Arctic have generated concern regarding a potential increase in human infections. However, whole genome sequencing (WGS) of the organism was unable to identify a zoonotic origin for this case.\ud \ud Conclusions: \ud Consideration should be given to E. rhusiopathiae as a cause of joint infections if the appropriate epidemiologic and host risk factors exist. Expanded use of WGS in other potential animal hosts and environmental sources may provide important epidemiologic information in determining the source of human infections. |
| Databáze: | OpenAIRE |
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