A potential diagnostic pitfall for hobnail variant of papillary thyroid carcinoma

Autor:	Tiffany Y. Chen, Matthew A. Nehs, Gerard M. Doherty, Erik K. Alexander, Kristine S. Wong, Justine A. Barletta, Brooke E. Howitt, Sara E Higgins, Jochen H. Lorch, Nancy L. Cho, Ellen Marqusee
Rok vydání:	2020
Předmět:	Adult Male 0301 basic medicine medicine.medical_specialty Histology endocrine system diseases Improved survival Gastroenterology Pathology and Forensic Medicine Thyroid carcinoma Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Atypia medicine Humans Thyroid Neoplasms Aged business.industry Clinical course Mean age General Medicine Middle Aged medicine.disease 030104 developmental biology Thyroid Cancer Papillary Tumour size 030220 oncology & carcinogenesis Cohort Ki67 index Female business
Zdroj:	Histopathology. 76:707-713
ISSN:	1365-2559 0309-0167
Popis:	AIMS Hobnail variant of papillary thyroid carcinoma (PTC) is an aggressive PTC subtype characterised by a hobnail cytomorphology. However, some classic PTC have a 'hobnail-like' cytomorphology associated with thick, hyalinised, variably oedematous fibrovascular cores that appears to be a form of ischaemic/degenerative atypia. METHODS AND RESULTS We studied three cohorts to compare the histopathological characteristics and clinical outcome of 'hobnail-like' classic PTC and true hobnail variant of PTC: cohort 1, PTC consecutively resected between 2016 and 2017 (to assess frequency of 'hobnail-like' cytomorphology); cohort 2, 20 'hobnail-like' classic PTC resected between 2005 and 2007 (to assess clinical outcome); and cohort 3, seven true hobnail variant of PTC. A 'hobnail-like' cytomorphology was identified in 16% of consecutively resected PTC. Compared with true hobnail variant, 'hobnail-like' classic PTC occurred in younger patients (mean age 40 years versus 68 years, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aea688d29aa19fac8a6e5c1f8d4eb2c https://doi.org/10.1111/his.14042 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.