Effectiveness of Sorafenib in Hepatic Hemangioma
| Autor: | Kanchan Muhrerkar, Bhanu Jayanand Sunil, Ayloor Seshadri Ramakrishnan, Prateek Tiwari, Trivadi S. Ganesan, Vandana Mahajan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Sorafenib
Cancer Research medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Case Report Asymptomatic lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine medicine Humans Chemotherapy Aged business.industry Liver Neoplasms Jaundice medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens eye diseases Abdominal mass Radiation therapy Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Heart failure Liver Hemangioma 030211 gastroenterology & hepatology Female sense organs Radiology medicine.symptom business Hemangioma medicine.drug |
| Zdroj: | Journal of Global Oncology Journal of Global Oncology, Vol 4, Pp 1-4 (2017) |
| ISSN: | 2378-9506 |
| Popis: | Hemangiomas are the most common benign tumors of the liver, with a frequency of 0.4% to 7.3%.1 Small liver hemangiomas (< 4 cm) are generally asymptomatic and can be observed without any chance of malignant transformation or complications. Hemangiomas are defined as giant if their size exceeds 4 cm.2 The most common site is the right lobe of the liver (subcapsular region). Small, asymptomatic hemangiomas do not show changes during long-term follow-up; hence they can be observed without any treatment.3 Giant liver hemangiomas are symptomatic and patients present with mild pain, abdominal mass, abdominal fullness and rarely with jaundice, consumptive coagulopathy (Kasabach-Merritt syndrome), or intra-abdominal bleeding as the result of rupture. Congestive heart failure and intraperitoneal bleeding can sometimes be fatal.4 Surgical resection is the only treatment option for symptomatic hemangiomas. Diagnosis is not easy to obtain because percutaneous biopsy is risky and the role of other treatment options such as steroids, hepatic artery ligation, and radiotherapy is controversial.5 Herein, we report an unusual case of a giant symptomatic hepatic hemangioma, which was initially diagnosed as an inoperable hepatocellular carcinoma (HCC) and treated with an oral tyrosine kinase inhibitor (ie, sorafenib). |
| Databáze: | OpenAIRE |
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