Eyeglasses-based tear biosensing system: Non-invasive detection of alcohol, vitamins and glucose
| Autor: | Gulcin Bolat, Valtencir Zucolotto, Guangda Tang, Laís Canniatti Brazaca, Juliane R. Sempionatto, Joseph Wang, Rupesh K. Mishra, Alberto Escarpa, Jayoung Kim, Rushabh Shah, Alan Campbell, Aída Martín, Laura García-Carmona |
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| Rok vydání: | 2019 |
| Předmět: |
Computer science
Biomedical Engineering Biophysics Wearable computer Biosensing Techniques 02 engineering and technology 01 natural sciences Article Wearable Electronic Devices Electrochemistry GLICOSE Humans Alcohol measurement Wearable technology Monitoring Physiologic business.industry 010401 analytical chemistry Non invasive Electrochemical detector Vitamins General Medicine 021001 nanoscience & nanotechnology eye diseases 0104 chemical sciences Eyeglasses Glucose Alcohols Tears Alcohol intake sense organs 0210 nano-technology business Biosensor Biotechnology Biomedical engineering |
| Zdroj: | Biosens Bioelectron Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0956-5663 |
| Popis: | We report on a wearable tear bioelectronic platform, integrating a microfluidic electrochemical detector into an eyeglasses nose-bridge pad, for non-invasive monitoring of key tear biomarkers. The alcohol-oxidase (AOx) biosensing fluidic system allowed real-time tear collection and direct alcohol measurements in stimulated tears, leading to the first wearable platform for tear alcohol monitoring. Placed outside the eye region this fully wearable tear-sensing platform addresses drawbacks of sensor systems involving direct contact with the eye as the contact lenses platform. Integrating the wireless electronic circuitry into the eyeglasses frame thus yielded a fully portable, convenient-to-use fashionable sensing device. The tear alcohol sensing concept was demonstrated for monitoring of alcohol intake in human subjects over multiple drinking courses, displaying good correlation to parallel BAC measurements. We also demonstrate for the first time the ability to monitor tear glucose outside the eye and the utility of wearable devices for monitoring vitamin nutrients in connection to enzymatic flow detector and rapid voltammetric scanning, respectively. These developments pave the way to build an effective eyeglasses system capable of chemical tear analysis. |
| Databáze: | OpenAIRE |
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