Nicotinanilides as inhibitors of neutrophil chemotaxis
| Autor: | Nathan C. Ihle, Rocky Ursino, Kristin A. Kucera, John Latham, Neil S. Cutshall |
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| Rok vydání: | 2002 |
| Předmět: |
Human neutrophil
Neutrophils Chemistry Neutrophile Organic Chemistry Clinical Biochemistry Nicotinic Acids Pharmaceutical Science Chemotaxis Pharmacology Ligands Biochemistry In vitro Neutrophil chemotaxis Chemotaxis Leukocyte Inhibitory Concentration 50 Structure-Activity Relationship Drug Discovery Humans Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 12:1517-1520 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(02)00188-9 |
| Popis: | A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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