Mucosal Associated Invariant T Cells Were Activated and Polarized Toward Th17 in Chronic Obstructive Pulmonary Disease
Autor: | Yongjun Cai, Haiyan Ge, Li Xiao, Huili Zhu, Yanxu Wu, Wenjia Qiu, Ning Kang |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
0301 basic medicine lcsh:Immunologic diseases. Allergy medicine.medical_treatment Immunology Inflammation Mucosal associated invariant T cell Lymphocyte Activation Mucosal-Associated Invariant T Cells mucosal associated invariant T cell chronic obstructive pulmonary disease interleukin-17 Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Immune system Immunopathology medicine cytokine Humans Immunology and Allergy Aged Original Research COPD Lung business.industry Cell Differentiation Middle Aged medicine.disease respiratory tract diseases 030104 developmental biology Cytokine medicine.anatomical_structure 030220 oncology & carcinogenesis Cytokines Th17 Cells Female activation Interleukin 17 medicine.symptom business lcsh:RC581-607 |
Zdroj: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
ISSN: | 1664-3224 |
Popis: | Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by airway limitation accompanied with infiltration of inflammatory cells. Mucosal associated invariant T (MAIT) cells can recognize bacteria and play an important role in controlling host immune responses by producing cytokines. In this study, we characterized the function and the ability of MAIT cells to secrete cytokines measured by flow cytometry. In COPD patients, MAIT cells have the ability to produce more IL-17 and less IFN-γ compared to healthy individuals. We found that HLA-DR expression levels reflected the degree of inflammation and the proportion of IL-17 was significantly correlated with lung function in peripheral blood. In addition, we found that MAIT cells were highly expressed in the lung, and the increased expression of CXCR2, CXCL1 indicated that MAIT cells had the potential to migrate to inflammatory tissues. This evidence implies that MAIT cells may play a potential role in COPD immunopathology. |
Databáze: | OpenAIRE |
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