IL-6-174 G/C and -572 C/G polymorphisms and risk of Alzheimer's disease
| Autor: | Sheng Bi, Shu Rong Duan, Shi Rong Wen, Zheng Yi Qu, Shu Qin Wei, Hui Ping Qi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Anatomy and Physiology Science Immunology Inheritance Patterns Disease Gastroenterology Polymorphism Single Nucleotide Alzheimer Disease Internal medicine Immune Physiology Genotype medicine Genetics Odds Ratio Humans Genetic Predisposition to Disease Genetic Testing Interleukin 6 Biology Genetic Association Studies Clinical Genetics Multidisciplinary biology Interleukin-6 Neurodegenerative Diseases Odds ratio Molecular Development Confidence interval Neurology Immune System biology.protein Genetic Polymorphism Cytokines Medicine Dominant model Clinical Immunology Population Genetics Research Article Developmental Biology |
| Zdroj: | PLoS ONE, Vol 7, Iss 6, p e37858 (2012) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Associations between interleukin 6 (IL-6) polymorphisms and Alzheimer’s disease (AD) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations for the relationship between IL-6-174 G/C and -572 C/G polymorphisms and risk for AD. Electronic searches for all publications in databases PubMed and EMBASE were conducted on the associations between IL-6 polymorphisms and risk for AD until January 2012. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated using fixed and random effects models. Twenty-seven studies were included with a total of 19,135 individuals, involving 6,632 AD patients and 12,503 controls. For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs. CG+GG: OR = 0.65, 95%CI = 0.52–0.82). As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs. CC: OR = 0.73, 95% CI = 0.62–0.86) and in additive model (GG vs. CC, OR = 0.66, 95% CI = 0.46–0.96). In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD. |
| Databáze: | OpenAIRE |
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