No selection of CXCR4-using variants in cell reservoirs of dual-mixed HIV-infected patients on suppressive maraviroc therapy
| Autor: | Jacques Izopet, Stéphanie Raymond, Michelle Cazabat, Florence Nicot, Pierre Delobel, Lise Cuzin, Mary Requena, Nicolas Jeanne, Romain Carcenac |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genotype Anti-HIV Agents viruses 030106 microbiology Immunology HIV Infections CCR5 receptor antagonist CXCR4 Peripheral blood mononuclear cell Virus Maraviroc 03 medical and health sciences chemistry.chemical_compound Cyclohexanes Immunology and Allergy Medicine Hiv infected patients Humans Selection Genetic business.industry HIV High-Throughput Nucleotide Sequencing Triazoles Virology Viral Tropism Infectious Diseases chemistry Tissue tropism Leukocytes Mononuclear business |
| Zdroj: | AIDS (London, England). 30(6) |
| ISSN: | 1473-5571 |
| Popis: | We used ultradeep sequencing to investigate the evolution of the frequency of CXCR4-using viruses in the peripheral blood mononuclear cells of 22 patients infected with both CCR5 and CXCR4-using viruses treated with the CCR5 antagonist maraviroc for 24 weeks and a stable antiviral therapy. The mean CXCR4-using virus frequency in peripheral blood mononuclear cells was 59% before maraviroc intensification and 52% after 24 weeks of effective treatment, indicating no selection by maraviroc. |
| Databáze: | OpenAIRE |
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