Correction: The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory
| Autor: | Leanne J M Schmitz, Remco V Klaassen, Marta Ruiperez-Alonso, Azra Elia Zamri, Jasper Stroeder, Priyanka Rao-Ruiz, Johannes C Lodder, Rolinka J van der Loo, Huib D Mansvelder, August B Smit, Sabine Spijker |
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| Rok vydání: | 2018 |
| Předmět: |
long-term potentiation (LTP)
synaptic plasticity General Immunology and Microbiology Mouse QH301-705.5 Science General Neuroscience musculoskeletal neural and ocular physiology Glutamate receptor Shisa General Medicine General Biochemistry Genetics and Molecular Biology nervous system Medicine auxiliary protein protein interaction Biology (General) Research Article Neuroscience |
| Zdroj: | eLife eLife, Vol 7 (2018) |
| ISSN: | 2050-084X |
| Popis: | Glutamatergic synapses rely on AMPA receptors (AMPARs) for fast synaptic transmission and plasticity. AMPAR auxiliary proteins regulate receptor trafficking, and modulate receptor mobility and its biophysical properties. The AMPAR auxiliary protein Shisa7 (CKAMP59) has been shown to interact with AMPARs in artificial expression systems, but it is unknown whether Shisa7 has a functional role in glutamatergic synapses. We show that Shisa7 physically interacts with synaptic AMPARs in mouse hippocampus. Shisa7 gene deletion resulted in faster AMPAR currents in CA1 synapses, without affecting its synaptic expression. Shisa7 KO mice showed reduced initiation and maintenance of long-term potentiation of glutamatergic synapses. In line with this, Shisa7 KO mice showed a specific deficit in contextual fear memory, both short-term and long-term after conditioning, whereas auditory fear memory and anxiety-related behavior were normal. Thus, Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics of AMPARs, necessary for synaptic hippocampal plasticity, and memory recall. |
| Databáze: | OpenAIRE |
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